AHA / ASA Scientific Statement Vascular Contributions to Cognitive Impairment and Dementia
AHA / ASA Scientific Statement Vascular Contributions to Cognitive Impairment and Dementia
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发表时间：
2011
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通讯作者：
P. Gorelick;A. Scuteri;S. Black;C. DeCarli;S. Greenberg;C. Iadecola;L. Launer;S. Laurent;
中科院分区：
文献类型：
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作者：
P. Gorelick;A. Scuteri;S. Black;C. DeCarli;S. Greenberg;C. Iadecola;L. Launer;S. Laurent;
背景和目的-本科学声明概述了血管在认知障碍和痴呆中的作用。血管对认知障碍和晚年痴呆的贡献是常见的。血管性认知功能障碍（VCI）的定义，神经病理学，基础科学和病理生理学方面，神经影像学和血管和其他相关的危险因素的作用，以及潜在的机会，预防和治疗进行了审查。本声明作为从业人员的总体指南，以更好地了解VCI和痴呆症，预防和治疗。多年来，基于临床前，神经病理学，神经影像学，生理学和流行病学研究。建议采用跨学科、翻译和交易的方法，以进一步了解这一实体，并更好地描述其神经心理学特征。有必要进行前瞻性、定量、临床病理学神经影像学研究，以提高对神经影像学变化的病理基础以及临床VCI和阿尔茨海默病演变中血管和阿尔茨海默病病理之间复杂相互作用的认识。可能需要早在中年开始的长期血管风险标记物干预研究，以预防或推迟VCI和阿尔茨海默病的发作。另一个重要的研究途径是深入研究如何减少高危人群中的血管危险因素。（中风。2011;42：2672-2713）。
Background and Purpose —This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia. Vascular contributions to cognitive impairment and dementia of later life are common. Definitions of vascular cognitive impairment (VCI), neuropathology, basic science and pathophysiological aspects, role of neuroimaging and vascular and other associated risk factors, and potential opportunities for prevention and treatment are reviewed. This statement serves as an overall guide for practitioners to gain a better understanding of VCI and dementia, prevention, and treatment. years, based on preclinical, neuropathologic, neuroimaging, physiological, and epidemiological studies. Transdisciplinary, translational, and transactional approaches are recommended to further our understanding of this entity and to better characterize its neuropsychological profile. There is a need for prospective, quantitative, clinical-pathological-neuroimaging studies to improve knowledge of the pathological basis of neuroimaging change and the complex interplay between vascular and Alzheimer disease pathologies in the evolution of clinical VCI and Alzheimer disease. Long-term vascular risk marker interventional studies beginning as early as midlife may be required to prevent or postpone the onset of VCI and Alzheimer disease. Studies of intensive reduction of vascular risk factors in high-risk groups are another important avenue of research. ( Stroke . 2011;42:2672-2713.)