Functions of autophagy in the tumor microenvironment and cancer metastasis.
Functions of autophagy in the tumor microenvironment and cancer metastasis.
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DOI：
10.1111/febs.14388
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Macleod KF
中科院分区：
文献类型：
--
作者：
Mowers EE;Sharifi MN;Macleod KF
自噬是一种古老而高度保守的自我降解过程，通过清除细胞器、病原体和蛋白质聚集体在正常细胞中发挥稳态作用。自噬，正如它通常所提到的那样，还允许细胞通过回收自噬降解的副产物（如脂肪酸、氨基酸和核苷酸）来维持代谢充足并在营养应激条件下存活。肿瘤细胞比正常细胞更依赖于自噬来存活，部分原因是它们的快速生长速率、改变的代谢和营养缺乏的生长环境。肿瘤细胞对自噬的这种依赖性如何影响它们向恶性肿瘤和转移性疾病的进展是越来越多的研究焦点的领域。在这里，我们回顾了最近的工作，确定自噬在肿瘤细胞迁移和侵袭，肿瘤干细胞维持和治疗抗性以及肿瘤细胞与其微环境之间的串扰中的关键功能。自噬是上调的肿瘤进展成为恶性肿瘤，这篇评论地址自噬如何调节癌症转移。具体而言，我们研究了自噬在肿瘤细胞迁移和侵袭中发挥的关键作用，在维持癌症干细胞表型和肿瘤细胞休眠以及自噬如何影响肿瘤细胞与肿瘤微环境组分的相互作用。最后，我们讨论了这些功能如何使自噬抑制成为转移性癌症的一种有吸引力的治疗选择。
Macro-autophagy is an ancient and highly-conserved self-degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens and protein aggregates. Autophagy, as it is routinely referred to, also allows cells to maintain metabolic sufficiency and survive under conditions of nutrient stress by recycling the by-products of autophagic degradation, such as fatty acids, amino acids and nucleotides. Tumor cells are more reliant than normal cells on autophagy for survival in part due to their rapid growth rate, altered metabolism and nutrient deprived growth environment. How this dependence of tumor cells on autophagy affects their progression to malignancy and metastatic disease is an area of increasing research focus. Here, we review recent work identifying critical functions for autophagy in tumor cell migration and invasion, tumor stem cell maintenance and therapy resistance and cross-talk between tumor cells and their microenvironment. Autophagy is upregulated as tumors progress to become malignant and this review addresses how autophagy modulates cancer metastasis. Specifically, we examine the critical role played by autophagy in tumor cell migration and invasion, in maintaining the cancer stem cell phenotype and tumor cell dormancy as well as how autophagy affects interactions of tumor cells with components of the tumor microenvironment. Finally, we discuss how these functions make autophagy inhibition an attractive therapeutic option for metastatic cancers.
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DOI：
10.1158/1078-0432.ccr-13-3227
发表时间：
2014-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cook KL;Wärri A;Soto-Pantoja DR;Clarke PA;Cruz MI;Zwart A;Clarke R
通讯作者：
Clarke R
影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
影响因子：
11.2
作者：
Akalay, Intissar;Janji, Bassam;Chouaib, Salem
通讯作者：
Chouaib, Salem
影响因子：
11.2
作者：
Belaid A;Cerezo M;Chargui A;Corcelle-Termeau E;Pedeutour F;Giuliano S;Ilie M;Rubera I;Tauc M;Barale S;Bertolotto C;Brest P;Vouret-Craviari V;Klionsky DJ;Carle GF;Hofman P;Mograbi B
通讯作者：
Mograbi B
影响因子：
11.8
作者：
Carroll, Bernadette;Mohd-Naim, Noor;Maximiano, Filipe;Frasa, Marieke A.;McCormack, Jessica;Finelli, Mattea;Thoresen, Sigrid B.;Perdios, Louis;Daigaku, Reiko;Francis, Richard E.;Futter, Clare;Dikic, Ivan;Braga, Vania M. M.
通讯作者：
Braga, Vania M. M.