Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons
Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons
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DOI：
10.1093/aje/kwx330
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发表时间：
2018-05-01
影响因子：
5
通讯作者：
Grodstein, Francine
中科院分区：
文献类型：
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作者：
Samieri, Cecilia;Morris, Martha-Clare;Grodstein, Francine
鱼是长链 omega-3 脂肪酸的主要来源，可能有助于延缓认知衰老。我们汇集了来自法国三城市研究和 4 个美国队列（护士健康研究、妇女健康研究、芝加哥健康和老龄化项目以及 Rush 记忆和老龄化项目）的参与者（n = 23,688 名白人，年龄 >= 65 岁，88% 女性，基线年份范围为 1992-1999 年，中位随访范围为 3.9-9.1 年）进行调查研究鱼类摄入量与认知能力下降的关系，并检查与阿尔茨海默病相关基因的相互作用。我们使用线性混合模型估计了鱼类与全局认知和情景记忆综合得分变化之间的特定群体关联，并使用逆方差加权荟萃分析汇总了结果。在多变量分析中，较高的鱼类摄入量与整体认知和记忆力下降较慢相关（趋势 P = 4 份/周，而
Fish are a primary source of long-chain omega-3 fatty acids, which may help delay cognitive aging. We pooled participants from the French Three-City study and 4 US cohorts (Nurses' Health Study, Women's Health Study, Chicago Health and Aging Project, and Rush Memory and Aging Project) for whom diet and cognitive data were available (n = 23,688 white persons, aged >= 65 years, 88% female, baseline year range of 1992-1999, and median follow-up range of 3.9-9.1 years) to investigate the relationship of fish intake to cognitive decline and examine interactions with genes related to Alzheimer disease. We estimated cohort-specific associations between fish and change in composite scores of global cognition and episodic memory using linear mixed models, and we pooled results using inverse-variance weighted meta-analysis. In multivariate analyses, higher fish intake was associated with slower decline in both global cognition and memory (P for trend = 4 servings/week versus