Immune modulation of stem cells and regeneration.

Immune modulation of stem cells and regeneration.
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DOI:
10.1016/j.stem.2014.06.009
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发表时间:
2014-07-03
期刊:
影响因子:
23.9
通讯作者:
Olson, Eric N.
Olson, Eric N.
中科院分区:
医学1区
文献类型:
--
作者:
Aurora, Arin B.;Olson, Eric N.

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The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart and the nervous system. Here, we discuss key findings that implicate inflammatory cells and their secreted factors in tissue replacement following injury via stem cells and other reparative mechanisms. We highlight clinical conditions that are amenable to immune-mediated regeneration and suggest immune targeting strategies for tissue regeneration.
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