EVIDENCE OF ENHANCED STORAGE CAPACITY IN ADIPOSE-TISSUE OF GENETICALLY FAT CHICKENS
EVIDENCE OF ENHANCED STORAGE CAPACITY IN ADIPOSE-TISSUE OF GENETICALLY FAT CHICKENS
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DOI：
10.1093/jn/119.10.1369
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发表时间：
1989-10-01
影响因子：
4.2
通讯作者：
LECLERCQ, B
中科院分区：
文献类型：
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作者：
HERMIER, D;QUIGNARDBOULANGE, A;LECLERCQ, B
研究了两种肥胖鸡品系(分别为脂肪品系和瘦肉品系)腹部脂肪组织中血浆甘油三酯的储存能力。对2周龄和5周龄雏鸡的脂肪组织细胞密度和脂蛋白脂酶(LPL)活性进行了评估。在2周龄雏鸡中，对间质血管部分的细胞密度、脂联素和甘油磷酸脱氢酶(GPDH)活性进行了评估。在研究的两个年龄段，脂肪线显示出成熟脂肪细胞数量的两倍增加和明显的肥大。无论营养状况如何，每种细胞的LPL活性都不受基因型的影响；然而，肥鸡的每一整块脂肪的LPL活性更高。在2周龄肥鸡中，间质血管部分以细胞数量增加和LPL活性降低为特征，而GPDH没有变化。最后，脂肪线上脂肪细胞的过度增殖似乎反映了前体细胞的过度增殖。肥禽LPL活性较高的主要原因是细胞增殖，而不是脂肪细胞的内在活性较高。因此，脂肪组织对脂肪酸的摄取增强是确定鸡肥胖的一个主要因素。
The storage capacity for plasma triglyceride in abdominal adipose tissue has been investigated in two lines of chickens selected for either high or low adiposity (fat line and lean line, respectively). Adipose tissue cellularity and lipoprotein lipase (LPL) activity were estimated in 2- and 5-wk-old birds. In 2-wk-old birds, cellularity and LPL and glycerophosphate dehydrogenase (GPDH) activity were evaluted in the stromavascular fraction. At both ages studied, the fat line exhibited a twofold increase in mature fat cell number and a marked hypertrophy. LPL activity per cell did not differ with genotype, regardless of the nutritional state; however, LPL activity per whole fat pad was higher in fat birds. In 2-wk-old fat chickens, the stromasvascular fraction was characterized by an increase in cell number and a decrease in LPL activity, while GPDH was unchanged. Finally, adipocyte hyperplasia in the fat line appeared to reflect an excessive proliferation of precursor cells. The higher LPL activity in fat birds resulted mainly from cell hyperplasia, rather than from a greater intrinsic activity of adipocytes. Consequently, enhanced fatty acid uptake by adipose tissue represents a major factor in determination of adiposity in the chicken.