ACYCLIC STEREOCONTROL THROUGH THE ALDOL CONDENSATION
ACYCLIC STEREOCONTROL THROUGH THE ALDOL CONDENSATION
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DOI：
10.1126/science.214.4519.395
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
HEATHCOCK, CH
中科院分区：
文献类型：
--
作者：
HEATHCOCK, CH
对于想要合成复杂有机化合物的科学家来说，最困难的问题往往是在合成过程中在各个手性中心建立正确的构型。在过去的十年里，人们越来越努力地寻找这个问题的直接解决方案，这在无环和其他构象柔性分子的合成中尤为突出。最古老的有机反应之一，羟醛缩合，正在成为实现这种立体控制的有力工具。
For the scientist who wishes to synthesize complex organic compounds, the most difficult problem is often establishing the correct configuration at the various chiral centers as the synthesis is being carried out. In the past decade, there has been an increasing effort to find direct solutions to this problem, which is particularly acute in the synthesis of acyclic and other conformationally flexible molecules. One of the oldest organic reactions, the aldol condensation, is emerging as a powerful tool for use in achieving such stereocontrol.