Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis
Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis
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DOI：
10.1542/peds.2009-1901
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发表时间：
2010-02-01
期刊：
影响因子：
8
通讯作者：
Gentsch, Jon R.
中科院分区：
文献类型：
--
作者：
Payne, Daniel C.;Edwards, Kathryn M.;Gentsch, Jon R.
虽然轮状病毒疫苗已知是通过粪便脱落的，但据我们所知，疫苗衍生病毒向未接种疫苗的接触者传播导致有症状的轮状病毒胃肠炎的报道尚未见报道。我们在这里记录了疫苗衍生轮状病毒(RotaTeq[Merck and Co，Whitehouse Station，NJ])从接种疫苗的婴儿传播给年龄较大的未接种疫苗的兄弟姐妹的情况，导致需要急诊科护理的症状性轮状病毒胃肠炎。我们的调查结果表明，P7[5]G1和P1a[8]G6基因的疫苗成分毒株在复制过程中在接种疫苗的婴儿或年长的兄弟姐妹中发生了重新分配，增加了这种重新分配可能增加了疫苗衍生病毒的毒力的可能性。这两名儿童在事件发生11个月后仍然健康，没有潜在的医疗条件。儿科2010；125：e438-e441
Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care. Results of our investigation suggest that reassortment between vaccine component strains of genotypes P7[5] G1 and P1A[8] G6 occurred during replication either in the vaccinated infant or in the older sibling, raising the possibility that this reassortment may have increased the virulence of the vaccine-derived virus. Both children remain healthy 11 months after this event and are without underlying medical conditions. Pediatrics 2010;125:e438-e441