Avian H5N1 influenza in cats
Avian H5N1 influenza in cats
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DOI：
10.1126/science.1102287
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发表时间：
2004-10-08
期刊：
影响因子：
56.9
通讯作者：
Osterhaus, A
中科院分区：
文献类型：
--
作者：
Kuiken, T;Rimmelzwaan, G;Osterhaus, A
2003年至2004年亚洲爆发甲型禽流感（H5N1）病毒期间，有家猫感染致命的传闻，尽管该物种被认为对流感有抵抗力。我们实验性地给猫气管内接种 H5N1 病毒，并喂它们感染病毒的鸡。这些猫排出病毒，出现严重的弥漫性肺泡损伤，并将病毒传播给哨兵猫。这些结果表明，家猫面临H5N1病毒感染或死亡的风险，可以通过水平传播感染，并可能在该病毒的流行病学中发挥作用。
During the 2003 to 2004 outbreak of avian influenza A (H5N1) virus in Asia, there were anecdotal reports of fatal infection in domestic cats, although this species is considered resistant to influenza. We experimentally inoculated cats with H5N1 virus intratracheally and by feeding them virus-infected chickens. The cats excreted virus, developed severe diffuse alveolar damage, and transmitted virus to sentinel cats. These results show that domestic cats are at risk of disease or death from H5N1 virus, can be infected by horizontal transmission, and may play a role in the epidemiology of this virus.