The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth.
The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth.
复制标题
在腹水肝癌生长过程中，抗癌酶 DT 黄酶在肝脏中被选择性诱导。
作者：
R. E. Beyer;J. Segura;L. Ernster
DT黄递酶催化两个电子转移到醌类，形成相对稳定的对苯二酚，从而保护细胞免受半醌产生和随后超氧自由基形成的损害。一个快速和实质性的增加DT黄递酶的活性发生在细胞质和微粒体组分的肝脏与Zajelovic腹水肝癌的条件下，一般抑制其他外源性代谢酶的活性。这种增加是时间依赖性的，与生长的肝癌细胞的DT黄递酶的比活性的增加平行，并且仅限于肝脏。用肝癌细胞质治疗大鼠导致肝细胞质DT黄递酶活性以剂量依赖性方式快速增加。
DT diaphorase catalyzes the transfer of two electrons to quinones to form relatively stable hydroquinones, thus protecting cells from damage by semiquinone production and subsequent superoxide radical formation. A rapid and substantial increase in the activity of DT diaphorase occurs in the cytosolic and microsomal fractions of livers of rats with Zajdela ascites hepatoma under conditions which generally depress the activity of other xenobiotic-metabolizing enzymes. The increase is time-dependent, parallels the increase in the specific activity of DT diaphorase of the growing hepatoma cells, and is limited to the liver. Treatment of rats with hepatoma cytosol results in a rapid increase in liver cytosolic DT diaphorase activity in a dose-dependent manner.