Moderate to vigorous physical activity and risk of upper-respiratory tract infection
Moderate to vigorous physical activity and risk of upper-respiratory tract infection
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DOI：
10.1097/00005768-200208000-00003
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发表时间：
2002-08-01
期刊：
影响因子：
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通讯作者：
Hebert, JR
中科院分区：
文献类型：
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作者：
Matthews, CE;Ockene, IS;Hebert, JR
目的：体力活动与上呼吸道感染（URTI）风险之间的关系已被提出一个“J”形模型。然而，很少有流行病学证据支持适度活动的人患URTI的风险最低的论点。这项调查研究了不经常运动和适度运动的成年人之间URTI风险的差异。研究方法：对547名年龄在20-70岁之间的健康成年人（49%为女性）进行的观察性研究，在12个月的随访（5次评估）中，以90天的间隔报告了URTI事件。每次评估获得三次24小时体力活动回忆，并取平均值以量化总的中度-剧烈活动（大于或等于3.0代谢当量[MET]）。URTI和体力活动水平之间的关联是通过Poisson回归得出的发病率比（IRR）来估计的，同时调整了一些潜在的混杂因素，包括年龄、教育、焦虑、愤世嫉俗和选定的饮食因素。结果：男性和女性每年分别报告1.2（1.4）和1.2（1.2）例URTI事件（平均值[（SD）]）。调整性别和潜在混杂因素后，IRR小于3.93、3.94-7.15、7.16-11.95和大于或等于11.96 MET-h（.）d（-1），男性分别小于2.38、2.39-4.09、4.10-6.24和大于等于6.25 MET·h（.）d（-1）在女性中分别为1.00（参照）、0.87（95%置信区间[CI]，0.70-1.07）、0.88（95% CI，0.71-1.09）和0.77（95% CI，0.62-0.95）（P趋势= 0.03）。这种影响在男性（P趋势= 0.03）中比女性（P趋势= 0.17）更强，尽管在类似的支出水平（6-7 MET-h（.）d（-1）），男性和女性的风险降低约20%。风险降低在当年秋季最为明显（P趋势= 0.02）。结论：这些数据支持这一假设，即适度的体力活动与URTI风险降低有关。
Purpose: A "J"-shaped model has been proposed to describe the relationship between physical activity and risk of upper-respiratory tract infection (URTI). However, little epidemiologic evidence is available to support the contention that moderately active individuals are at lowest risk of URTI. This investigation examined differences in URTI risk between physically inactive and moderately active adults. Methods: Observational study of 547 healthy adults (49% women) aged 20-70 yr reported URTI events at 90-d intervals over 12-month of follow-up (5 evaluations). Three 24-h physical activity recalls per evaluation were obtained and averaged to quantify total moderate-vigorous activity (greater than or equal to3.0 metabolic equivalents [MET]). Associations between URTI and physical activity levels were estimated using incidence rate ratios (IRR) derived using Poisson regression while adjusting for a number of potential confounders including age, education, anxiety, cynicism, and selected dietary factors. Results: Men and women reported 1.2 (1.4) and 1.2 (1.2) URTI events per year, respectively (mean [(SD]). Adjusting for gender and potential confounders, the IRR for less than 3.93, 3.94-7.15, 7.16-11.95, and greater than or equal to 11.96 MET-h(.)d(-1) among men, and less than 2.38, 2.39-4.09, 4.10-6.24, and greater than or equal to 6.25 MET-h(.)d(-1) among women, were 1.00 (referent), 0.87 (95% confidence interval [CI], 0.70-1.07), 0.88 (95% CI, 0.71-1.09), and 0.77 (95% CI, 0.62-0.95), respectively (P-trend = 0.03). This effect was stronger in men (P-trend = 0.03) than women (P-trend = 0.17), although at similar expenditure levels (6-7 MET-h(.)d(-1)), risk was reduced by about 20% in men and women. Risk reduction was most pronounced in the fall of the year (P-trend = 0.02). Conclusions: These data support the hypothesis that moderate levels of physical activity are associated with a reduced risk for URTI.