Decreased motoneuron survival in Igf2 null mice after sciatic nerve transection.
Decreased motoneuron survival in Igf2 null mice after sciatic nerve transection.
复制标题
坐骨神经横断后 Igf2 缺失小鼠的运动神经元存活率降低。
DOI：
10.1097/wnr.0b013e328330b735
复制
发表时间：
2009
期刊：
影响因子：
1.7
通讯作者：
Lopez,MaryFrances
中科院分区：
文献类型：
--
作者：
Silva,Delia;Dikkes,Pieter;Barnes,Medina;Lopez,MaryFrances
寻找治疗靶点以防止神经元死亡的工作正在进行中，涉及探索一长串神经营养因子。胰岛素样生长因子2(IGF2)是胰岛素家族中的一员，具有已知的神经营养特性。在这项研究中，我们使用免疫球蛋白2基因敲除(−/−)新生小鼠来确定免疫球蛋白2缺陷是否损害轴突损伤后运动神经元的存活。结果表明，Igf2−/−新生小鼠比Igf2+/+小鼠更容易受到运动神经元损伤，因为它们在坐骨神经切断后运动神经元存活率显著降低。−/−小鼠给予IGF2后，神经元存活率显著提高。这些结果支持IGF2在新生运动神经元存活中的作用。
The search for therapeutic targets to prevent neurons from dying is ongoing and involves the exploration of a long list of neurotrophic factors. Insulin-like growth factor 2 (IGF2) is a member of the insulin family with known neurotrophic properties. In this study, we used Igf2 knockout (Igf2−/−) neonate mice to determine whether Igf2 deficiency is detrimental to motor neuron survival after axonal injury. Results show that Igf2−/− neonatal mice are more susceptible to motor neuron damage than Igf2+/+ mice, as they have a significantly lower percentage of motor neuron survival after a sciatic nerve transection. Neuronal survival was significantly improved in Igf2−/− mice when IGF2 was administered. These results support the role of IGF2 in neonatal motor neuron survival.