Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield
Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield
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DOI：
10.3389/fnmol.2020.00061
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发表时间：
2020-04-23
影响因子：
4.8
通讯作者：
Young, W. Scott
中科院分区：
文献类型：
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作者：
Cymerblit-Sabba, Adi;Smith, Adam S.;Young, W. Scott
社会认知是社会决策的基础，也是行为复杂的社会群体建立持久亲和行为的基础。这是建立对社会伙伴或群体成员的选择性偏好的关键一步。C57 BL/6 J实验室小鼠不形成一夫一妻制关系，并且通常不会对熟悉的小鼠表现出长期的社会偏好。CA 2海马子区在社会记忆中起着至关重要的作用，并且在短的记忆获得期间对背侧CA 2场的输入的光遗传学刺激可以增强和延长小鼠的社会记忆。在这里，我们表明，在小鼠的伴侣偏好可以诱导的化学选择性刺激的单突触的预测从下丘脑室旁核（PVN）的CA 2在同居期间。具体来说，雄性老鼠花更多的时间在社会接触，梳理和蜷缩与合作伙伴相比，一个新的女性。偏好并没有诱导延长同居期，并允许更多的时间进行社会交往和男性与熟悉的女性交配。这些结果表明，PVN-CA 2的预测是一个进化保守的神经回路的一部分，潜在的社会偏好的形成，并可能促进行为的变化与适当的刺激。
Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous relationships, and typically do not show prolonged social preferences for familiar mice. The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 field during a short memory acquisition period can enhance and extend social memories in mice. Here, we show that partner preference in mice can be induced by chemogenetic selective stimulation of the monosynaptic projections from the hypothalamic paraventricular nucleus (PVN) to the CA2 during the cohabitation period. Specifically, male mice spend more time in social contact, grooming and huddling with the partner compared to a novel female. Preference was not induced by prolonging the cohabitation period and allowing more time for social interactions and males to sire pups with the familiar female. These results suggest that PVN-to-CA2 projections are part of an evolutionarily conserved neural circuitry underlying the formation of social preference and may promote behavioral changes with appropriate stimulation.