Analysis of inner and outer retinal layers using spectral domain optical coherence tomography automated segmentation software in ocular hypertensive and glaucoma patients.
Analysis of inner and outer retinal layers using spectral domain optical coherence tomography automated segmentation software in ocular hypertensive and glaucoma patients.
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DOI：
10.1371/journal.pone.0196112
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Martinez-de-la-Casa JM
中科院分区：
文献类型：
--
作者：
Cifuentes-Canorea P;Ruiz-Medrano J;Gutierrez-Bonet R;Peña-Garcia P;Saenz-Frances F;Garcia-Feijoo J;Martinez-de-la-Casa JM
目的：应用海德堡光谱光学相干断层扫描(SD-OCT)图像分割软件，分析正常、高眼压和原发性开角型青光眼患者黄斑视网膜8层的形态特征和诊断能力。单中心、横断面、非干预性研究。193例193只眼(56例对照组，63例眼压增高者，32例早期原发性开角型青光眼和42例中晚期原发性开角型青光眼)。排除了那些有任何视网膜疾病的患者。视网膜层的黄斑分割是使用新的海德堡光谱OCT软件自动执行的，该软件提供了对8个视网膜层的测量。该软件提供分为九个子域的厚度图。4组间内层厚度差异均有统计学意义。高眼压组与早期青光眼组比较，黄斑视网膜神经纤维层上、下段，鼻侧、颞段、上、下段神经节细胞层和内网状层差异有统计学意义。早期青光眼诊断ROC曲线下面积：黄斑部视网膜神经纤维层外下部0.781±0.052，神经节细胞层外颞部0.760±0.050，内丛层0.767±0.049，外颞部0.807±0.048。在考虑视网膜外层时，两组之间没有发现差异。海德堡光谱OCT的自动分割软件为诊断高眼压和青光眼患者提供了一种新的诊断工具。
To analyse the morphological features and diagnostic ability of eight macular retinal layers using a new segmentation software Heidelberg's Spectralis Optical Coherence Tomography (SD-OCT) in healthy, ocular hypertensive and primary open angle glaucoma patients. Single-center, cross-sectional, non-interventional study. 193 eyes from 193 consecutive patients (56 controls, 63 ocular hypertensives, 32 early primary open glaucoma patients and 42 moderate-advanced primary open glaucoma patients). Those patients presenting any retinal disease were excluded. Macular segmentation of the retinal layers was automatically performed using the new segmentation Heidelberg's Spectralis OCT software providing measurements for eight retinal layers. The software provides thickness maps divided into nine subfields. Statistically significant differences in inner layers’ thickness was found between all 4 four groups. Superior and inferior sectors of macular retinal nerve fiber layer; nasal, temporal, superior and inferior sectors of ganglion cell layer and inner plexiform layer were significantly different when comparing ocular hypertensive patients and early glaucoma patients. Areas under the ROC curves for early glaucoma diagnosis were 0.781±0.052 for macular retinal nerve fiber layer outer inferior sector, 0.760±0.050 for ganglion cell layer outer temporal sector, 0.767±0.049 for the inner plexiform layer outer temporal sector and 0.807±0.048 for the combination of all three. No differences were found between groups when considering outer retinal layers. The automated segmentation software from Heidelberg's Spectralis OCT provides a new diagnostic tool for the diagnosis of ocular hypertensive and glaucoma patients.