Patterns of content, contextual, and working memory impairments in schizophrenia and nonamnesic alcoholism.
Patterns of content, contextual, and working memory impairments in schizophrenia and nonamnesic alcoholism.
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DOI：
10.1037//0894-4105.11.2.195
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发表时间：
1997-04
期刊：
影响因子：
2.4
通讯作者：
E. Sullivan;P. Shear;R. Zipursky;Harvey J. Sagar;A. Pfefferbaum
中科院分区：
文献类型：
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作者：
E. Sullivan;P. Shear;R. Zipursky;Harvey J. Sagar;A. Pfefferbaum
本研究使用内容记忆(对单词和抽象设计的项目识别)、上下文记忆(对言语和非言语项目的顺序再认)和工作记忆(短保持间隔的再认)的测试来考察27名精神分裂症患者、52名慢性酒精中毒患者和66名健康对照受试者的操作模式。当年龄和智商调整后，精神分裂症组在言语和非言语材料的项目和顺序再认上显着受损；酗酒组仅在对这两种材料的顺序再认上受损。精神分裂症组的物品和顺序识别缺陷在最短的保持间隔时最严重，这是之前在帕金森氏症患者中观察到的模式，表明精神分裂症患者的工作记忆缺陷突出。
This study used tests of content memory (item recognition of words and abstract designs), context memory (order recognition of verbal and nonverbal items), and working memory (recognition at a short retention interval) to examine patterns of performance in 27 schizophrenic patients, 52 chronic alcoholic patients, and 66 healthy control participants. When performance was age- and IQ-adjusted the schizophrenia group was significantly impaired in item and order recognition of verbal and nonverbal material; the alcoholic group was impaired only in order recognition for both material types. Item- and order-recognition deficits in the schizophrenia group were greatest at the shortest retention intervals, a pattern previously observed in patients with Parkinson's disease, suggesting a prominence of a working memory deficit in schizophrenia.