Associations of allostatic load with sleep apnea, insomnia, short sleep duration, and other sleep disturbances: findings from the National Health and Nutrition Examination Survey 2005 to 2008
Associations of allostatic load with sleep apnea, insomnia, short sleep duration, and other sleep disturbances: findings from the National Health and Nutrition Examination Survey 2005 to 2008
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DOI：
10.1016/j.annepidem.2014.05.014
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发表时间：
2014-08-01
影响因子：
5.6
通讯作者：
Williams, Michelle A.
中科院分区：
文献类型：
--
作者：
Chen, Xiaoli;Redline, Susan;Williams, Michelle A.
目的：研究非稳态负荷（AL），跨生物系统的累积生理失调的措施，是否与睡眠呼吸暂停，失眠，和其他sleep disturbances.Methods：数据从全国健康和营养调查2005-2008年被使用。AL使用代表心血管、炎症和代谢系统功能的9种生物标志物进行测量。结果：高AL（AL评分>= 3）的患病率在非裔美国人中最高（26.3%），其次是西班牙裔美国人（20.3%）、白人（17.7%）和其他种族/民族（13.8%）。在调整社会人口统计学和生活方式因素后，高AL与睡眠呼吸暂停显著相关（比值比[OR]，1.92; 95%置信区间[Cl]，1.40-2.63），打鼾（OR，2.20; 95%CI，1.79-2.69）、打鼾/停止呼吸（OR，2.16; 95%CI，1.46-3.21）、睡眠潜伏期延长（OR，1.42; 95%CI，1.08-1.88）、睡眠时间短（
Purpose: To examine whether allostatic load (AL), a measure of cumulative physiologic dysregulation across biological systems, was associated with sleep apnea, insomnia, and other sleep disturbances.Methods: Data from the National Health and Nutrition Examination Survey 2005-2008 were used. AL was measured using nine biomarkers representing cardiovascular, inflammatory, and metabolic system functioning. A total of 3330 US adults aged 18 years and older were included in this study.Results: The prevalence of high AL (AL score >= 3) was the highest among African Americans (26.3%), followed by Hispanic Americans (20.3%), whites (17.7%), and other racial/ethnic group (13.8%). After adjustment for sociodemographic and lifestyle factors, high AL was significantly associated with sleep apnea (odds ratio [OR], 1.92; 95% confidence interval [Cl], 1.40-2.63), snoring (OR, 2.20; 95% Cl, 1.79-2.69), snorting/stop breathing (OR, 2.16; 95% Cl, 1.46-3.21), prolonged sleep latency (OR, 1.42; 95% Cl, 1.08-1.88), short sleep duration (