Conversion to sirolimus: A useful strategy for recalcitrant cutaneous viral warts in liver transplant recipient
Conversion to sirolimus: A useful strategy for recalcitrant cutaneous viral warts in liver transplant recipient
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DOI：
10.1002/lt.20927
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发表时间：
2006-12-01
影响因子：
4.6
通讯作者：
Pruvot, Francois Rene
中科院分区：
文献类型：
--
作者：
Dharancy, Sebastien;Catteau, Benoit;Pruvot, Francois Rene
移植后的皮肤并发症非常常见，大多数免疫抑制移植受者由于人乳头瘤病毒（HPV）感染而发展出一些到许多疣。在免疫抑制的情况下，治疗管理可能是令人失望的，因为患者的病变程度无法产生足够的针对HPV的免疫应答。我们在此报告一例年轻的肝移植受者，她因感染弥漫性的HPV引起的疣而导致生活质量下降。考虑到靶向雷帕霉素（TOR）抑制剂，一类新的免疫抑制药物的抗增殖和细胞抑制特性，我们显着修改的免疫抑制方案。转换为西罗莫司后，皮肤状态迅速改善，这表明这种策略可能是有用的移植受体的皮肤病毒疣。
Dermatological complications following transplantation are very common and the majority of immunosuppressed transplant recipients develop some to many warts due to human papillomavirus (HPV) infection. In the setting of immunosuppression, therapeutic management may be disappointing because of the extent of the lesions in patients unable to develop a sufficient immune response directed against HPV. We report here a case of a young liver transplant recipient who developed diffuse recalcitrant HPV-induced warts leading to an impairment of her quality of life. Taking into account the antiproliferative and cytostatic properties of the target-of-rapamycin (TOR) inhibitors, a new class of immunosuppressive drug, we significantly modified the immunosuppressive regimen. Conversion to sirolimus was followed by a rapid improvement of cutaneous state suggesting that this strategy may be useful for recalcitrant cutaneous viral warts in transplant recipient.