Renal action of C-type natriuretic peptide: advocating the isolated perfused rat kidney model.
Renal action of C-type natriuretic peptide: advocating the isolated perfused rat kidney model.
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发表时间：
2010-07
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通讯作者：
P. Hu;Ling Lu;Bo Hu;Yuan-Han Qin
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作者：
P. Hu;Ling Lu;Bo Hu;Yuan-Han Qin
C型利尿钠肽（CNP）是已确定的第三种利尿钠肽（NP），主要表达于神经系统和内皮细胞。此外，CNP被认为是在正常人肾脏的肾小管细胞和肾小球中局部产生的。 CNP 主要发挥血管舒张和抗有丝分裂作用，而不是通过自分泌或旁分泌途径调节体液稳态。许多因素，如剪切力、促炎细胞因子和脂多糖，可以在体内和体外调节CNP的产生和排泄。然而，过去从离体灌注大鼠肾脏模型中获得的关于CNP肾脏作用的信息很少，在该模型中可以以受控方式改变变量并消除全身影响。然而，回顾使用该模型的研究数据，我们得出这样的结论：该模型可以成为探索 CNP 肾脏作用未被发现的方面的有用工具，并且应该在未来的研究中得到提倡。
C-type natriuretic Peptide (CNP), the third natriuretic peptide (NP) identified, is mainly expressed in the nervous system and endothelial cells. In addition, CNP is believed to be produced locally in tubular cells and glomeruli of normal human kidneys. CNP exerts mainly vasodilatory and antimitogenetic effects rather than regulation of body fluid homeostasis via autocrine or paracrine pathway. Many factors, such as shear, pro-inflammatory cytokines and lipopolysaccharide, can regulate the production and excretion of CNP both in vivo and in vitro. However, little information about the renal action of CNP was obtained in the past from the model of isolated perfused rat kidney in which variables could be changed in a controlled manner and systemic influences could be eliminated. However, reviewing the data from the studies that used this model inspires us to conclude that such model can be a useful tool to probe the undiscovered aspects of the renal actions of CNP and should be advocated for future studies on it.