miR-26a suppresses tumour proliferation and metastasis by targeting metadherin in triple negative breast cancer
miR-26a suppresses tumour proliferation and metastasis by targeting metadherin in triple negative breast cancer
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miR-26a通过靶向三阴性乳腺癌中的metadherin抑制肿瘤增殖和转移
DOI：
10.1016/j.canlet.2014.11.050
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发表时间：
2015-02-01
期刊：
影响因子：
9.7
通讯作者：
Xie, Xiaoming
中科院分区：
文献类型：
--
作者：
Liu, Peng;Tang, Hailin;Xie, Xiaoming
据报道，miR-26a在多种癌症中发挥重要作用。在本研究中，我们发现miR-26a在三阴性乳腺癌（TNBC）中下调，其表达水平与TNBC的淋巴结转移和总生存期相关。我们还发现，miR-26a的异位表达通过下调MTDH（miR-26a'靶基因）mRNA和蛋白来抑制体外和体内TNBC细胞的增殖和转移，并且MTDH的过表达可以部分消除miR-26a介导的抑制。我们的数据表明，miR-26a 在 TNBC 发展中充当肿瘤抑制因子，并作为乳腺癌的预后标志物。 (c) 2014 Elsevier Ireland Ltd. 保留所有权利。
It has been reported that miR-26a plays an important role in various cancers. In this study, we found that miR-26a was downregulated in triple-negative breast cancer (TNBC), and its expression levels were associated with lymph node metastasis and overall survival in TNBC. We also found that the ectopic expression of miR-26a inhibited TNBC cell proliferation and metastasis in vitro and in vivo by downregulating MTDH (a miR-26a' target gene) mRNA and protein and that the overexpression of MTDH could partially abrogate miR-26a-mediated suppression. Our data suggest that miR-26a functions as a tumour suppressor in TNBC development and serves as a prognostic marker for breast cancer. (c) 2014 Elsevier Ireland Ltd. All rights reserved.