Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation.
Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation.
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DOI：
10.1016/j.visres.2017.06.016
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发表时间：
2017-10
期刊：
影响因子：
1.8
通讯作者：
Grant MB
中科院分区：
文献类型：
--
作者：
Bhatwadekar AD;Duan Y;Korah M;Thinschmidt JS;Hu P;Leley SP;Caballero S;Shaw L;Busik J;Grant MB
糖尿病的广泛性影响个体的所有器官系统，包括骨髓。骨髓细胞和细胞外成分的长期损伤导致骨髓造血干/祖细胞（HS/PC）区室的快速下降。这篇综述将强调骨髓微环境在维持骨髓HS/PC人群中的重要性，以及这些关键人群在糖尿病自然史微血管修复中的贡献。自主神经系统可以启动和传播糖尿病骨髓功能障碍。旨在保护骨髓-HS/PC人群免受糖尿病诱导的氧化应激和晚期糖基化终产物蓄积的全身药理学策略代表了靶向糖尿病视网膜病变进展的新方法。保护HS/PC确保它们参与血管修复并降低视网膜中发生血管变性的风险。
The widespread nature of diabetes affects all organ systems of an individual including the bone marrow. Long-term damage to the cellular and extracellular components of the bone marrow leads to a rapid decline in the bone marrow-hematopoietic stem/progenitor cells (HS/PCs) compartment. This review will highlight the importance of bone marrow microenvironment in maintaining bone marrow HS/PC populations and the contribution of these key populations in microvascular repair during the natural history of diabetes. The autonomic nervous system can initiate and propagate bone marrow dysfunction in diabetes. Systemic pharmacological strategies designed to protect the bone marrow-HS/PC population from diabetes induced-oxidative stress and advanced glycation end product accumulation represent a new approach to target diabetic retinopathy progression. Protecting HS/PCs ensures their participation in vascular repair and reduces the risk of vasogdegeneration occurring in the retina.
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影响因子：
7.7
作者：
Bhatwadekar AD;Yan Y;Qi X;Thinschmidt JS;Neu MB;Li Calzi S;Shaw LC;Dominiguez JM;Busik JV;Lee C;Boulton ME;Grant MB
通讯作者：
Grant MB
影响因子：
7.7
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影响因子：
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