Gene targeting in Aspergillus fumigatus by homologous recombination is facilitated in a nonhomologous end-joining-deficient genetic background
Gene targeting in Aspergillus fumigatus by homologous recombination is facilitated in a nonhomologous end-joining-deficient genetic background
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DOI：
10.1128/ec.5.1.212-215.2006
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Braus, GH
中科院分区：
文献类型：
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作者：
Krappmann, S;Sasse, C;Braus, GH
akuA基因编码Ku70组件的非同源末端连接机械删除的机会致病菌烟曲霉。没有明显的表型可以评估相应的突变株，但同源重组的相对频率增加，从靶向漆酶编码abr2基因推断。
The akuA gene encoding the Ku70 component of the nonhomologous end-joining machinery was deleted in the opportunistic pathogen Aspergillus fumigatus. No obvious phenotype could be assessed for the corresponding mutant strain but relative frequencies of homologous recombination were increased as deduced from targeting the laccase-encoding abr2 gene.