Neural correlates of semantic priming for ambiguous words: An event-related fMRI study
Neural correlates of semantic priming for ambiguous words: An event-related fMRI study
复制标题
DOI：
10.1016/j.brainres.2006.11.016
复制
发表时间：
2007-02-02
期刊：
影响因子：
2.9
通讯作者：
Eastburn, Matt
中科院分区：
文献类型：
--
作者：
Copland, David A.;de Zubicaray, Greig I.;Eastburn, Matt
我们研究了语义启动的神经相关性，通过使用事件相关的功能磁共振成像记录血氧水平依赖（BOLD）的反应，而参与者进行快速的词汇决策（词/非词）视觉呈现相关与不相关的启动目标对。采用1000 ms的长刺激起始时间，这允许增加受控处理和基于选择性频率的歧义启动。条件包括一个模糊的词prime（例如bank）和一个与其主导意义（例如money）或从属意义（例如river）相关的目标。与不相关的条件相比，启动优势目标与LIFG，右前扣带回和上级颞回的活动增加，这表明词汇语义整合机制，而增加的右超边缘活动的不相关的条件是一致的期望为基础的启动。次级目标没有启动，并与减少活动主要是在枕颞区与单词识别，这可能是一致的频率为基础的意义抑制。这些发现为语义启动的神经机制和词汇歧义抑制机制的功能解剖学相关性提供了新的视角。(c)2006 Elsevier B. V.保留所有权利。
We investigated the neural correlates of semantic priming by using event-related fMRI to record blood oxygen level dependent (BOLD) responses while participants performed speeded lexical decisions (word/nonword) on visually presented related versus unrelated prime-target pairs. A long stimulus onset asynchrony of 1000 ms was employed, which allowed for increased controlled processing and selective frequency-based ambiguity priming. Conditions included an ambiguous word prime (e.g. bank) and a target related to its dominant (e.g. money) or subordinate meaning (e.g. river). Compared to an unrelated condition, primed dominant targets were associated with increased activity in the LIFG, the right anterior cingulate and superior temporal gyrus, suggesting postlexical semantic integrative mechanisms, while increased right supramarginal activity for the unrelated condition was consistent with expectancy based priming. Subordinate targets were not primed and were associated with reduced activity primarily in occipitotemporal regions associated with word recognition, which may be consistent with frequency-based meaning suppression. These findings provide new insights into the neural substrates of semantic priming and the functional-anatomic correlates of lexical ambiguity suppression mechanisms. (c) 2006 Elsevier B.V. All rights reserved.