Cognitive impairment in multiple sclerosis.
Cognitive impairment in multiple sclerosis.
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DOI：
10.1007/s11910-012-0294-3
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发表时间：
2012-10
影响因子：
5.6
通讯作者：
Kovner B
中科院分区：
文献类型：
--
作者：
Lovera J;Kovner B
认知障碍（CI）是MS的一种严重并发症，受影响的领域已经确立，但新的受影响领域（如心理理论）仍在确定中。一些疾病修饰疗法（DMT）可以改善和预防MS中CI发展的证据并不可靠。最近的研究流行CI MS，虽然没有固体的研究之前完成的DMT介绍，表明CI仍然是一个问题，即使在人们对DMT，甚至在MS的最早阶段。功能磁共振成像研究和扩散纤维束成像研究表明，病变对认知的影响取决于特定的皮质网络的影响和他们的可塑性。认知康复和L-安非他明似乎有希望的治疗，胆碱酯酶抑制剂和美金刚已经失败，银杏和运动的数据有限。我们需要更多的工作来了解和开发MS中CI的治疗方法。
Cognitive Impairment (CI) is a serious complication of MS, and the domains affected are well established but new affected domains such as theory of mind are still being identified. The evidence that some disease modifying therapies (DMTs) may improve and prevent the development of CI in MS is not solid. Recent studies on the prevalence CI in MS, although not as solid as studies completed prior to DMT introduction, suggest that CI remains a problem even among people on DMTs and even at the very earliest stages of MS. Functional MRI studies and studies using diffusion tractography show that the impact of lesions on cognition depends on the particular cortical networks affected and their plasticity. Cognitive rehabilitation and L-amphetamine appear promising treatments, cholinesterase inhibitors and memantine have failed, and data on Ginkgo and exercise are limited. We need more work to understand and develop treatment for CI in MS.