Current Concepts of Somatomedin and Other Biologically Related Growth Factors
Current Concepts of Somatomedin and Other Biologically Related Growth Factors
复制标题
生长调节素和其他生物学相关生长因子的当前概念
作者：
R. Chochinov;W. Daughaday
自从20年前发现生长激素的促生长作用是通过血清因子介导的以来，这一领域的研究迅速扩大。这是本次审查的目的，使这一领域的科学奋进的角度来看。本文的第一部分将讨论血清生长调节素的活性及其在健康和疾病中的生物学作用和测量。本文最后将对近年来分离纯化的生长调节素样物质：生长调节素A、B、C、非抑制性胰岛素样活性--可溶于酸性乙醇（NSILA-S）和增殖刺激活性（MSA）的一些物理和生物学特性进行综述。
Since the discovery 20 years ago that the growth-promoting effects of somatotropin are mediated through a serum factor(s), research in this area has rapidly expanded. It is the purpose of this review to bring this area of scientific endeavor into perspective. The first part of this review will deal with aspects of total serum somatomedin activity and its biologic actions and measurements in health and disease. The last part of this review will summarize some of the physical and biologic characteristics of the recently purified “somatomedin-like” substances: somatomedin A, B, and C, NSILA-S (nonsuppressible insulin-like activity-soluble in acid ethanol) and MSA (multiplication-stimulating activity).