Extended HLA haplotypes in Japanese homozygous typing cells.
Extended HLA haplotypes in Japanese homozygous typing cells.
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日本纯合分型细胞中扩展的 HLA 单倍型。
DOI：
10.1111/j.1399-0039.1998.tb03107.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
H. Inoko
中科院分区：
文献类型：
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作者：
T. Naruse;Y. Nose;R. Ando;N. Araki;A. Shigenari;A. Ando;M. Ishihara;M. Kagiya;N. Nabeya;G. Isshiki;H. Inoko
我们在33个日本HLA纯合分型细胞（HTC）中定义了扩展的HLA单倍型，包括HLA II类基因，非HLA基因如TAP 1、TAP 2和LMP 2，以及NOTCH 4基因内的（CTG）n微卫星重复序列。这些保守的单倍型的特点是独特的连锁可能会保持作为一个结果，它们之间的功能合作，在抗原呈递途径。这些HTC可以作为一个原始的和种族特异性的标准面板，提供有用的遗传标记，单倍型多样性，疾病关联，和人类学研究。
We have defined extended HLA haplotypes including the HLA class II genes, the non-HLA genes such as TAP1, TAP2 and LMP2, and the (CTG)n microsatellite repeats within the NOTCH4 gene between DRA and 21OH in 33 Japanese HLA homozygous typing cells (HTC). These conserved haplotypes characterized by unique linkage might be maintained as a result of functional co-operation among them in the antigen presentation pathway. These HTCs can be served as an original and ethnic-specific standard panel, providing useful genetic markers in haplotypic diversity, disease association, and anthropology studies.