IVD Development: Nucleus pulposus development and sclerotome specification.
IVD Development: Nucleus pulposus development and sclerotome specification.
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DOI：
10.1007/s40610-018-0100-3
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发表时间：
2018-09-01
期刊：
影响因子：
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通讯作者：
Serra, Rosa
中科院分区：
文献类型：
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作者：
Alkhatib, Bashar;Ban, Ga I;Serra, Rosa
回顾目的：椎间盘（IVD）来源于胚胎脊索和硬膜。髓核来源于脊索，而脊柱的其他结缔组织来源于硬核组。本文将回顾过去5年IVD发展的研究。最近的发现：在过去的几年中，在了解控制髓核和纤维环发育的阶梯过程方面取得了进展。从诱导或胚胎干细胞到髓核和近轴中胚层衍生组织的生成已经在体外通过正常发育确定的途径完成。BMP和tgf - β信号以及转录因子（包括Pax1/Pax9、Mkx和Nkx3.2）之间的平衡似乎对产生IVD组织的细胞命运决定非常重要。摘要：了解IVD如何发展将为未来IVD疾病的修复、再生和组织工程策略提供基础。
PURPOSE OF REVIEW: Intervertebral discs (IVD) are derived from embryonic notochord and sclerotome. The nucleus pulposus is derived from notochord while other connective tissues of the spine are derived from sclerotome. This manuscript will review the past 5 years of research into IVD development.RECENT FINDINGS: Over the past several years, advances in understanding the step-wise process that govern development of the nucleus pulposus and the annulus fibrosus have been made. Generation of tissues from induced or embryonic stem cells into nucleus pulposus and paraxial mesoderm derived tissues has been accomplished in vitro using pathways identified in normal development. A balance between BMP and TGF-beta signaling as well as transcription factors including Pax1/Pax9, Mkx and Nkx3.2 appear to be very important for cell fate decisions generating tissues of the IVD.SUMMARY: Understanding how the IVD develops will provide the foundation for future repair, regeneration, and tissue engineering strategies for IVD disease.