Multiple roles of caspase-8 in cell death, inflammation, and innate immunity.
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity.
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DOI：
10.1002/jlb.3mr0420-305r
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发表时间：
2021-01
影响因子：
5.5
通讯作者：
Lien E
中科院分区：
文献类型：
--
作者：
Orning P;Lien E
caspase -8是一种顶端caspase，参与细胞凋亡的程序性死亡形式，对哺乳动物的发育和免疫至关重要。与其他类型的程序性细胞死亡（如坏死或焦亡）相比，细胞凋亡历来被描述为免疫沉默。最近的报告表明，这些不同形式的细胞死亡之间存在相当大的相互作用。越来越清楚的是，caspase-8具有许多非凋亡作用，参与多个过程，包括调节坏死性死亡（由受体相互作用的丝氨酸/苏氨酸激酶，RIPK1-RIPK3介导），炎症细胞因子表达，炎症小体活化和白介素-1β和gasdermin D的裂解，以及对休克和微生物感染的保护。在这篇综述中，我们讨论了caspase-8在细胞死亡和炎症中的作用，并强调了它在先天免疫反应中的作用以及不同形式的细胞死亡之间的关系。Caspase-8是这类串音的核心成分之一。
Caspase-8 is an apical caspase involved in the programmed form of cell death called apoptosis that is critically important for mammalian development and immunity. Apoptosis was historically described as immunologically silent in contrast to other types of programmed cell death such as necroptosis or pyroptosis. Recent reports suggest considerable crosstalk between these different forms of cell death. It is becoming increasingly clear that caspase-8 has many non-apoptotic roles, participating in multiple processes including regulation of necroptosis (mediated by receptor-interacting serine/threonine kinases, RIPK1-RIPK3), inflammatory cytokine expression, inflammasome activation and cleavage of interleukin-1β and gasdermin D, and protection against shock and microbial infection. In this review, we discuss the involvement of caspase-8 in cell death and inflammation and highlight its role in innate immune responses and the relationship between different forms of cell death. Caspase-8 is one of the central components in this type of crosstalk.