Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures
Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures
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DOI：
10.1007/s00795-006-0349-0
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发表时间：
2007-09-01
影响因子：
1.8
通讯作者：
Lee, Gang-Hong
中科院分区：
文献类型：
--
作者：
Kuroda, Naoto;Iwamura, Shin-ichi;Lee, Gang-Hong
一名59岁的日本男性在十二指肠溃疡随访期间出现了一个巨大的粘膜下肿瘤伴溃疡。进行胰管切除术，随后的肿瘤组织学检查发现胰头未分化癌。癌成分包括腺癌和鳞癌。此外，未分化的梭形或多形性细胞与癌成分连续可见。未分化的肿瘤细胞，横纹肌样特征和透明的球状结构阳性PAS染色的酶预处理也被观察到。免疫组化，细胞质包涵体对应的横纹肌样特征显示波形蛋白的聚集。超微结构上，透明球状结构对应于溶酶体。最后，我们在这里报告的第一例胰腺间变性癌与透明球状结构。
A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and squamous cell carcinoma. Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component. Undifferentiated neoplastic cells with rhabdoid features and with hyaline globule-like structures positive for PAS stain with diastase pretreatment were also observed. Immunohistochemically, cytoplasmic inclusions corresponding to rhabdoid features showed aggregates of vimentin. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.