Development of a symptomatic intracranial meningioma in a male-to-female transsexual after initiation of hormone therapy
Development of a symptomatic intracranial meningioma in a male-to-female transsexual after initiation of hormone therapy
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DOI：
10.1016/j.jocn.2010.01.036
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发表时间：
2010-10-01
影响因子：
2
通讯作者：
Parsa, Andrew T.
中科院分区：
文献类型：
--
作者：
Delpolyi, Amy R.;Han, Seunggu J.;Parsa, Andrew T.
变性人患者接受常规的性激素治疗，这可能是脑膜瘤的一个风险因素，尽管数据在很大程度上是不确定的。在这里，我们描述了一名男性到女性的变性患者，使用雌二醇贴片治疗，他发展为枕骨脑膜瘤，导致全身癫痫发作。这是第二例男性变性为女性的患者在接受性激素治疗后发展为症状性脑膜瘤的报告，进一步证明性激素与脑膜瘤的发病有关。因此，脑膜瘤可能会使激素治疗复杂化，对于筛查发现脑膜瘤的变性候选人，性激素可能是禁忌。(C)2010爱思唯尔有限公司。保留所有权利，
Transsexual patients are routinely treated with sex hormone therapy, which may be a risk factor for meningiomas, although the data are largely inconclusive. Here we describe a male-to-female transsexual patient treated with estradiol patches, who developed an occipital meningioma causing generalized seizures. This is the second report of a male-to-female transsexual patient who developed a symptomatic meningioma after sex hormone treatment, adding to the growing evidence that sex hormones contribute to the pathogenesis of meningiomas. Meningiomas may therefore complicate hormone therapy and sex hormones may be contraindicated in transsexual candidates with meningiomas identified upon screening. (C) 2010 Elsevier Ltd. All rights reserved,