Experimental modeling of desensitization: What have we learned about preventing AMR?
Experimental modeling of desensitization: What have we learned about preventing AMR?
复制标题
DOI：
10.1111/ajt.15873
复制
发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Knechtle S
中科院分区：
文献类型：
--
作者：
Kwun J;Knechtle S
Over the last 5 decades, short-term outcomes in kidney transplantation have significantly improved, in large part due to reduced rates and severity of acute rejection. Development of better immunosuppressive maintenance agents, as well as new induction therapies, helped make these advances. Nonhuman primate models provided a rigorous testing platform to evaluate candidate biologics during this process. However, antibody-mediated rejection remains a major cause of late failure of kidney allografts despite advances made in pharmacologic immunosuppression and strategies developed to facilitate improved donor-recipient matching. Our lab has been actively working to develop strategies to prevent and treat antibody-mediated rejection and immunologic sensitization in organ transplantation, relying largely on a nonhuman primate model of kidney transplantation. In this review, we will cover outcomes achieved by managing antibody-mediated rejection or sensitization in nonhuman primate models and discuss promises, limitations, and future directions for this model.
登录
查看更多内容
影响因子：
15.3
作者：
GELUK, A;ELFERINK, DG;BONTROP, RE
通讯作者：
BONTROP, RE
影响因子：
6.2
作者：
Boskovic, Svjetlan;Kawai, Tatsuo;Cosimi, A. Benedict
通讯作者：
Cosimi, A. Benedict
影响因子：
6.2
作者：
Armstrong, N;Buckley, P;Knechtle, S
通讯作者：
Knechtle, S
影响因子：
6.2
作者：
Haanstra, KG;Sick, EA;Jonker, M
通讯作者：
Jonker, M
影响因子：
8.8
作者：
Espie, Pascal;He, YanLing;Gergely, Peter
通讯作者：
Gergely, Peter