Intrinsic network connectivity and own body perception in gender dysphoria.
Intrinsic network connectivity and own body perception in gender dysphoria.
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DOI：
10.1007/s11682-016-9578-6
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发表时间：
2017-08
影响因子：
3.2
通讯作者：
Savic I
中科院分区：
文献类型：
--
作者：
Feusner JD;Lidström A;Moody TD;Dhejne C;Bookheimer SY;Savic I
性别焦虑症（gender dysphoria，GD）是指一个人的身份与出生时的性别不一致。GD的生物学机制尚不清楚。我们研究了GD患者在自我背景下参与自身身体感知的脑网络连接模式。27名女性到男性（FtM）GD，27名男性对照，27名女性对照进行静息状态fMRI。我们使用独立成分分析比较了内在连接网络中的功能连接，这些内在连接网络涉及自我参照过程和自己的身体感知-默认模式网络（DMN）和显着性网络-以及视觉网络。网络连接的行为相关性也进行了测试，使用自我感知评级，同时查看自己的身体形象变形到他们出生时指定的性别，以及他们的性别认同的性别。与对照组相比，FtM表现出DMN内前、后扣带回和楔前叶的连通性降低。在FtM，更高的“自我”评级的机构变形对他们的性别认同的性别与更大的连接DMN内的前扣带，在长时间的观看。在对照组中，在短时间内，身体向出生时分配的性别变形的更高评级与显着性网络内的右下角连接有关。在视觉网络中，FtM在枕叶和颞叶区域的连接性较弱。结果表明，在GD中，在自我的背景下，参与自己的身体感知的网络内的断开连接。此外，作为内侧前额叶过程的一个功能，对身体与自我的关系的感知可能是反射性的，而不是反射性的。这些可能代表了身体感知和自我认同之间主观脱节的神经生物学相关性。
Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with GD, 27 male controls, and 27 female controls underwent resting state fMRI. We compared functional connections within intrinsic connectivity networks involved in self-referential processes and own body perception – default mode network (DMN) and salience network – and visual networks, using independent components analyses. Behavioral correlates of network connectivity were also tested using self-perception ratings while viewing own body images morphed to their sex assigned at birth, and to the sex of their gender identity. FtM exhibited decreased connectivity of anterior and posterior cingulate and precuneus within the DMN compared with controls. In FtM, higher “self” ratings for bodies morphed towards the sex of their gender identity were associated with greater connectivity of the anterior cingulate within the DMN, during long viewing times. In controls, higher ratings for bodies morphed towards their gender assigned at birth were associated with right insula connectivity within the salience network, during short viewing times. Within visual networks FtM showed weaker connectivity in occipital and temporal regions. Results suggest disconnectivity within networks involved in own body perception in the context of self in GD. Moreover, perception of bodies in relation to self may be reflective rather than reflexive, as a function of mesial prefrontal processes. These may represent neurobiological correlates to the subjective disconnection between perception of body and self-identification.