Four new bioactive lobane diterpenes of the soft coral Lobophytum pauciflorum from Mindoro, Philippines
Four new bioactive lobane diterpenes of the soft coral Lobophytum pauciflorum from Mindoro, Philippines
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DOI：
10.1021/np970276t
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发表时间：
1998-03-01
影响因子：
5.1
通讯作者：
van Ofwegen, LP
中科院分区：
文献类型：
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作者：
Edrada, RA;Proksch, P;van Ofwegen, LP
采集于菲律宾民多罗岛的海洋软珊瑚Lobophytom pauciflorum产生了4个新的龙须烷二萜衍生物：环氧三烯醇和洛三烯二醇的乙酸酯同系物(分别为2和7)，龙舌四烯的甲氧基同系物(10)和罗布三烯三醇的奥塞平同系物(11)，以及6个已知的衍生物(1，3-6和8)。新化合物的结构是根据核磁共振波谱((1)H，(13)C，COSY，(1)直接和长程(13)C-(1)H关联)和质谱学(EIMS)数据明确确定的。所有化合物均对植物病原真菌黄瓜枝孢霉有一定的抑制作用。化合物1对革兰氏阳性菌枯草芽孢杆菌和酵母具有抗菌活性。分离得到的龙须烷二萜化合物在卤水对虾致死试验中也具有活性。在后一种生物活性测定中，化合物8和10是活性最强的同系物，其LC(50)S分别为0.64和4.18微克/毫升。
The marine soft coral Lobophytum pauciflorum collected from Mindoro Island, Philippines, yielded four new lobane diterpene derivatives: the acetate congeners of epoxylobatrienol and lobatrienediol (2 and 7, respectively), a methoxyl congener of lobatetraene (10), and an oxepin congener of lobatrienetriol (11), and six known derivatives (1, 3-6, and 8). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, (1)H-detected direct, and long-range (13)C-(1)H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. Compound 1 was found to be active against the Gram-positive bacteria Bacillus subtilis and the yeast Saccharomyces cerevisiae. The isolated lobane diterpenes were also active in the brine shrimp lethality test. In the latter bioassay, compounds 8 and 10 were the most active congeners with LC(50)'s of 0.64 and 4.18 mu g/mL, respectively.