Fetal neurobehavioral development
Fetal neurobehavioral development
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DOI：
10.2307/1131640
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发表时间：
1996-10-01
影响因子：
4.6
通讯作者：
Johnson, TRB
中科院分区：
文献类型：
--
作者：
DiPietro, JA;Hodgson, DM;Johnson, TRB
胎儿自主神经，运动，状态和互动功能的个体发育进行了纵向研究，在31个健康胎儿的样本从20周到足月。在6个胎龄的50分钟多普勒胎儿监护期间收集胎心率和运动数据。胎儿心率和变异性，活动水平和活力，行为状态和反应性的措施来自这些数字化的数据。进行加权最小二乘分析以模拟发育模式并检查母体和胎儿协变量的作用。随着妊娠期的推进，胎仔心率减慢，心率变异性增加，运动行为减少但更剧烈，心率和运动模式合并为不同的行为状态，心脏对刺激的反应性增加。男性胎儿比女性胎儿更活跃，更大的母亲压力评估与胎儿心率变异性降低有关。在28至32周之间存在明显的神经行为转变期。对胎儿研究方法进行了评价。
The ontogeny of fetal autonomic, motoric, state, and interactive functioning was investigated longitudinally in a sample of 31 healthy fetuses from 20 weeks through term. Fetal heart rate and movement data were collected during 50 min of Doppler-based fetal monitoring at 6 gestational ages. Measures of fetal heart rate and variability, activity level and vigor, behavioral state, and reactivity were derived from these digitized data. Weighted least squares analyses were conducted to model the developmental patterns and to examine the role of maternal and fetal covariates. With advancing gestation, fetuses displayed slower heart rate, increased heart rate variability, reduced but more vigorous motor behavior, coalescence of heart rate and movement patterns into distinct behavioral states, and increasing cardiac responsivity to stimulation. Male fetuses were more active than female fetuses, and greater maternal stress appraisal was associated with reduced fetal heart rate variability. An apparent period of neurobehavioral transition exists between 28 and 32 weeks. Fetal research methods are evaluated.