Ovarian hyporesponsiveness to follicle stimulating hormone in adolescent girls born small for gestational age.
Ovarian hyporesponsiveness to follicle stimulating hormone in adolescent girls born small for gestational age.
复制标题
小于胎龄的青春期女孩的卵巢对卵泡刺激素反应低下。
DOI：
10.1210/jcem.85.7.6765
复制
发表时间：
2000
影响因子：
5.8
通讯作者：
F. de Zegher
中科院分区：
文献类型：
--
作者：
L. Ibáñez;N. Potau;F. de Zegher
出生前发育迟缓的女孩在出生时，原始卵泡的卵巢部分较小，在青春期，子宫和卵巢较小。我们现在已经研究了青春期女孩产前生长减少是否也伴随着FSH、FSH B和雌二醇之间关系的变化。我们研究了48名月经初潮后的女孩（年龄13.6 ± 1.4岁），她们出生时的体重与胎龄相当（阿加; n=33;平均体重3.3 Kg）或出生时的胎龄较小（SGA; n=15;平均体重2.4 Kg）。在卵泡早期（范围：第5 +/- 3天）测量血清FSH、卵泡抑素B和雌二醇浓度。与阿加女孩相比，SGA女孩的血清FSH升高（7.2 +/- 0.7 vs 4.5 +/- 0.3 IU/mL; p=0.0002），相似的雌二醇B（62.1 +/- 8.1 vs 60.7 +/- 6.5 pg/mL）和雌二醇浓度较低（12.1 +/- 1.5 vs 21.2 +/- 2.4 pg/mL; p=0.02）。因此，SGA女孩显示，初潮后早期，一种模式，指向卵巢颗粒细胞部分的低反应性，这是生殖老化的回忆。总之，产前生长受限的妇科相关性由此扩展到包括青春期卵巢对FSH的低反应性。
Girls with reduced prenatal growth are known to have, at birth, a small ovarian fraction of primordial follicles and, in adolescence, a uterus and ovaries of small size. We have now examined whether reduced prenatal growth is also followed by changes in the relationships among FSH, inhibin B and estradiol in adolescent girls. We studied 48 post-menarcheal girls (age 13.6 +/- 1.4 yr) who were either born with an appropriate weight for gestational age (AGA; n=33; mean weight 3.3 Kg) or born small for gestational age (SGA; n=15; mean weight 2.4 Kg). Serum FSH, inhibin B and estradiol concentrations were measured in the early follicular phase (range: day 5 +/- 3). SGA girls had, compared to AGA girls, elevated serum FSH (7.2 +/- 0.7 vs 4.5 +/- 0.3 IU/mL; p=0.0002), similar inhibin B (62.1 +/- 8.1 vs 60.7 +/- 6.5 pg/mL) and lower estradiol concentrations (12.1 +/- 1.5 vs 21.2 +/- 2.4 pg/mL; p=0.02). SGA girls thus displayed, early after menarche, a pattern that points to hyporesponsiveness of the ovarian granulosa cell fraction and that is reminiscent of reproductive aging. In conclusion, the gynecological correlates of prenatal growth restriction are herewith extended to include ovarian hyporesponsiveness to FSH in adolescence.