A multiple locus analysis of the collaborative study on the genetics of alcoholism data set.
A multiple locus analysis of the collaborative study on the genetics of alcoholism data set.
复制标题
酗酒遗传学合作研究数据集的多位点分析。
DOI：
10.1002/gepi.1370170739
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Wright,FA
中科院分区：
文献类型：
--
作者：
Lin,S;Irwin,ME;Wright,FA
Parametric and nonparametric statistical methods have been applied to the alcohol dependence data set collected in the Collaborative Study on the Genetics of Alcoholism (COGA). Our nonparametric linkage analyses (NPL) were based on the Sallstatistic of GENEHUNTER [Kruglyak et al., 1996] and the improved NPL statistic of GENEHUNTER‐PLUS [Kong and Cox, 1997]. Based on likely regions for alcohol susceptibility genes identified from our nonparametric analyses, we reanalyzed the data using several two‐locus models. We used the TMLINK program [Lathrop and Ott, 1990] in the LINKAGE package for these parametric analyses.
