Forebrain projections to the rostral nucleus of the solitary tract in the hamster
Forebrain projections to the rostral nucleus of the solitary tract in the hamster
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仓鼠孤束前脑向喙核的投射
DOI：
10.1002/1096-9861(20000703)422:3
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发表时间：
2000
影响因子：
2.5
通讯作者：
Katherine R. Holliday
中科院分区：
文献类型：
--
作者：
M. C. Whitehead;A. Bergula;Katherine R. Holliday
孤束嘴核(NST)是味觉信息加工的第一中枢部位。NST的特定解剖分区接受味觉传入输入，含有参与味觉上升或运动前通路的中间神经元和投射神经元。前脑投射到NST，可以影响味觉反应，但前脑输入与NST的细分及其细胞元素之间的解剖关系尚不清楚。为了评估这一点，在本研究中，我们使用霍乱毒素B(CTB)作为逆行和顺行标记物。将CTB注射到吻侧NST，通过逆行运输标记前脑输入的来源。在下丘脑外侧核和室旁核、终纹床核、杏仁中央核以及岛叶皮质的无颗粒和颗粒障碍区均有双侧标记细胞。在延髓内，标记细胞位于小细胞网状结构和三叉神经脊束核。此外，在注射对侧的吻侧NST也有标记细胞和顺行轴突标记。CTB注射集中在颗粒障碍的岛叶皮质，这是大多数前脑NST细胞的位置，标记的轴突终末仅限于吻侧NST。这些终末集中在吻部、中央部和腹侧部。位于吻侧中央分区的离皮质神经末梢的位置影响微电路，包括味觉传入突触、假定的抑制性中间神经元和投射到臂旁核的神经元。腹侧细分突触中的许多皮质分离末梢在运动前神经元之间连接，最终影响唾液和口腔运动的流出。NST注射后的延髓内CTB标记表明，吻侧中央区也接受对侧NST的投射。J.Comp.神经。422：429-447,2000。©2000 Wiley-Liss Inc.
The rostral nucleus of the solitary tract (NST) is the first central site of taste information processing. Specific anatomical subdivisions of the NST receive taste afferent input and contain interneurons and projection neurons that engage ascending or premotor taste pathways. The forebrain projects to the NST and can influence taste responses, but the anatomical relationship between forebrain inputs and the subdivisions of the NST and their cellular elements is not understood. To evaluate this, in this study, we used cholera toxin B (CTb) as a retrograde and anterograde marker. CTb was injected into the rostral NST to label, by retrograde transport, the sources of forebrain inputs. Cells were labeled bilaterally in the lateral and paraventricular hypothalamic nuclei, bed nucleus of the stria terminalis, central nuclei of the amygdala, and the agranular and dysgranular divisions of insular cortex. Within the medulla, labeled cells were located in the parvicellular reticular formation and spinal trigeminal nuclei. In addition, labeled cells and anterograde axonal labeling were present in the rostral NST contralateral to the injections. Injections of CTb centered in the dysgranular insular cortex, the site of most forebrain‐NST cells, labeled axon endings confined to the rostral NST. These endings were concentrated in the rostral central and ventral subdivisions. Corticofugal endings in the rostral central subdivision are positioned to influence microcircuits that include taste afferent synapses, presumed inhibitory interneurons, and neurons that project to the parabrachial nucleus. The many corticofugal endings in the ventral subdivision synapse among premotor neurons that ultimately influence salivatory and oromotor outflow. Intramedullary CTb labeling after NST injection indicates that the rostral central subdivision also receives projections from the contralateral rostral NST. J. Comp. Neurol. 422:429–447, 2000. © 2000 Wiley‐Liss, Inc.
大鼠脑干中的肝迷走神经和味觉传入相互作用。
DOI：
10.1016/0165-1838(83)90008-5
发表时间：
1983
期刊：
Journal of the autonomic nervous system
影响因子：
--
作者：
Hermann,GE;Kohlerman,NJ;Rogers,RC
通讯作者：
Rogers,RC