Vitamin D for Prevention and Treatment of Colorectal Cancer: What is the Evidence?
Vitamin D for Prevention and Treatment of Colorectal Cancer: What is the Evidence?
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DOI：
10.1007/s11888-014-0238-1
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发表时间：
2014-09-01
影响因子：
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通讯作者：
Ng, Kimmie
中科院分区：
文献类型：
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作者：
Ng, Kimmie
维生素D不足在美国非常普遍，尤其是在结肠直肠癌（CRC）患者中。这些低水平的维生素D是令人担忧的，因为越来越多的证据表明维生素D可能具有超越骨骼结果的健康益处。前瞻性观察性研究表明，较高的维生素D水平与较低的CRC发病风险相关，并改善了已确诊CRC患者的生存率，迫切需要随机临床试验来确定因果关系。此外，仍然非常需要改善CRC患者的预后，并且研究维生素D作为潜在的治疗方法在安全性和成本方面是一个有吸引力的选择，特别是在这个昂贵且通常有毒的抗肿瘤药物的时代。在这篇综述中，将总结有关维生素D在CRC中活性的证据，涵盖临床前、流行病学和临床研究，并讨论未来的研究方向。
Vitamin D insufficiency is highly prevalent in the U.S., particularly among colorectal cancer (CRC) patients. These low levels of vitamin D are concerning given increasing evidence that vitamin D may have health benefits beyond skeletal outcomes. Prospective observational studies suggest that higher vitamin D levels are associated with lower risk of incident CRC and improved survival for patients with established CRC, and randomized clinical trials are urgently needed to establish causality. Moreover, there remains a great need to improve prognosis for patients with CRC, and investigating vitamin D as a potential therapy is an attractive option in regards to safety and cost, particularly in this era of expensive and often toxic anti-neoplastic agents. In this review the evidence regarding the activity of vitamin D in CRC will be summarized, spanning preclinical, epidemiological, and clinical studies, and future research directions will be discussed.