The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases.
The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases.
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DOI：
10.3389/fimmu.2021.607641
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发表时间：
2021
影响因子：
7.3
通讯作者：
Hammond JW
中科院分区：
文献类型：
--
作者：
Qiu WQ;Luo S;Ma SA;Saminathan P;Li H;Gunnersen JM;Gelbard HA;Hammond JW
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders. All Sez6 family members contain 2-3 CUB domains and 5 complement control protein (CCP) domains, suggesting that they may be involved in complement regulation. We show that Sez6 family members inhibit C3b/iC3b opsonization by the classical and alternative pathways with varying degrees of efficacy. For the classical pathway, Sez6 is a strong inhibitor, Sez6L2 is a moderate inhibitor, and Sez6L is a weak inhibitor. For the alternative pathway, the complement inhibitory activity of Sez6, Sez6L, and Sez6L2 all equaled or exceeded the activity of the known complement regulator MCP. Using Sez6L2 as the representative family member, we show that it specifically accelerates the dissociation of C3 convertases. Sez6L2 also functions as a cofactor for Factor I to facilitate the cleavage of C3b; however, Sez6L2 has no cofactor activity toward C4b. In summary, the Sez6 family are novel complement regulators that inhibit C3 convertases and promote C3b degradation.
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影响因子：
5.3
作者：
Gorelik A;Sapir T;Woodruff TM;Reiner O
通讯作者：
Reiner O
DOI：
10.1038/ejhg.2015.218
发表时间：
2016-06
期刊：
European journal of human genetics : EJHG
影响因子：
--
作者：
Ambalavanan A;Girard SL;Ahn K;Zhou S;Dionne-Laporte A;Spiegelman D;Bourassa CV;Gauthier J;Hamdan FF;Xiong L;Dion PA;Joober R;Rapoport J;Rouleau GA
通讯作者：
Rouleau GA
影响因子：
64.8
作者：
Bialas, Allison R.;Presumey, Jessy;Carroll, Michael C.
通讯作者：
Carroll, Michael C.
影响因子：
4.4
作者：
Barilla-LaBarca, ML;Liszewski, MK;Atkinson, JP
通讯作者：
Atkinson, JP
影响因子：
5.3
作者：
An, Ning;Zhao, Yaqin;Yi, Cheng
通讯作者：
Yi, Cheng