RhoA, RhoB and RhoC have different roles in cancer cell migration
RhoA, RhoB and RhoC have different roles in cancer cell migration
复制标题
DOI：
10.1111/jmi.12025
复制
发表时间：
2013-09-01
影响因子：
2
通讯作者：
Ridley, A. J.
中科院分区：
文献类型：
--
作者：
Ridley, A. J.
众所周知，Rho GTP酶通过激活多种下游效应蛋白（包括酶、衔接蛋白和肌动蛋白成核剂）来调节细胞运动性。三种密切相关的Rho GTP酶RhoA、RhoB和RhoC都有可能与相同的下游效应物相互作用，但它们对细胞形状和迁移特性具有显著不同的影响。在这里，我回顾了RhoA，RhoB和RhoC表达在癌症中调节的不同方式，以及它们如何在癌症进展中发挥不同的作用。我描述了他们的主要效应已知有助于细胞运动。我们实验室和其他实验室的最新结果表明，RhoA，RhoB和RhoC可以被特定刺激激活，并通过不同的效应子来控制癌细胞迁移和侵袭的不同方面。这表明它们通过参与不同的蛋白质复合物而对癌症做出独特的贡献。
Rho GTPases are well known to regulate cell motility through activation of a variety of downstream effector proteins, including enzymes, adaptor proteins and actin nucleators. The three closely related Rho GTPases RhoA, RhoB and RhoC all have the potential to interact with the same downstream effectors, yet they have substantially different effects on cell shape and migratory properties. Here I review the different ways in which RhoA, RhoB and RhoC expression is regulated in cancer and how they play distinct roles in cancer progression. I describe their main effectors known to contribute to cell motility. Recent results from our laboratory and others indicate that RhoA, RhoB and RhoC can be activated by specific stimuli and act through different effectors to control distinct aspects of cancer cell migration and invasion. This suggests that they each make unique contributions to cancer by participating in different protein complexes.