Expression of vascular endothelial growth factor receptors in the endometrium of septate uterus
Expression of vascular endothelial growth factor receptors in the endometrium of septate uterus
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DOI：
10.1016/j.fertnstert.2008.07.1768
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发表时间：
2009-09-01
影响因子：
6.7
通讯作者：
Bonilla-Musoles, Fernando
中科院分区：
文献类型：
--
作者：
Raga, Francisco;Maria Casan, Eva;Bonilla-Musoles, Fernando
目的：比较血管内皮生长因子（VEGF）受体的信使RNA（mRNA）表达（KDR，Flt-1，和sflt）在纵隔子宫和正常子宫的不同子宫内膜位置。设计：前瞻性，观察性研究。设置：大学教学医院。患者：12名接受宫腔镜子宫成形术的完全纵隔子宫妇女和12名正常子宫妇女。干预：子宫内膜组织样品从覆盖隔膜的子宫内膜和衬于子宫侧壁的子宫内膜获得。结果：VEGF受体KDR和Flt-1的mRNA在纵隔内膜中的表达明显低于纵隔内膜和正常子宫内膜。相反，没有差异，观察可溶性受体SFLT的mRNA表达在不同的子宫内膜samples studied. Conclusions（S）：结果表明，局部缺陷的VEGF transmembranous受体（KDR和Flt-1）在子宫内膜覆盖的隔膜区可能是负责这种苗勒异常的临床comportment。（Fertil Steril（R）2009;92：1085-90。（C）2009年由美国生殖医学协会。
Objective: To compare the messenger RNA (mRNA) expression of vascular endothelial growth factor (VEGF) receptors (KDR, Flt-1, and sflt) in the different endometrial locations of septate uterus and normal uterus.Design: Prospective, observational study.Setting: University teaching hospital.Patient(s): Twelve women with complete septate uterus undergoing hysteroscopic metroplasty and 12 women with normal uterus.Intervention(s): Endometrial tissue samples were obtained from the endometrium covering the septum and the endometrium lining the lateral wall of the uterus. Moreover, endometrial samples were obtained from patients with normal uterus.Main Outcome Measure(s): Differences in the mRNA expression of VEGF receptors between the endometrial samples of septate and normal uterus.Result(s): The mRNA expression of VEGF receptors, both KDR and Flt-1, was significantly lower in the endometrium lining the septum as compared with the endometrium covering the lateral wall of septate and normal uterus. Conversely, no differences were observed in mRNA expression in the soluble receptor sflt between the different endometrial samples studied.Conclusion(s): The results suggest that a local defect of both VEGF transmembranous receptors (KDR and Flt-1) in the endometrium covering the septal area may be responsible for the clinical comportment of this mullerian anomaly. (Fertil Steril (R) 2009;92:1085-90. (C)2009 by American Society for Reproductive Medicine.)