Heavy drinking is associated with deficient response inhibition in women but not in men
Heavy drinking is associated with deficient response inhibition in women but not in men
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DOI：
10.1016/j.pbb.2009.04.015
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发表时间：
2009-09-01
影响因子：
3.6
通讯作者：
Wiers, Reinout W.
中科院分区：
文献类型：
--
作者：
Nederkoorn, Chantal;Baltus, Marcus;Wiers, Reinout W.
不良的反应抑制与广泛的问题行为有关，包括成瘾行为，并且可能代表一般的脆弱性因素。反应抑制的标准测试使用中性刺激。在这里，我们测试了重度饮酒者的反应抑制缺陷是否会对与他们的问题（酒精）相关的刺激更强。反应抑制是通过停止信号任务来评估的，使用四类图片：与酒精有关的，软饮料，色情（控制食欲类别）和中性图片。参与者是32名重度饮酒者和32名轻度饮酒者。鉴于最近的研究报告称，在大量饮酒的女性中，反应抑制解除可能最为明显，因此对两组饮酒的男性和女性进行了相同数量的测试。主要结果是：第一，两组在反应抑制方面没有发现区域特异性差异。其次，重度饮酒女性表现出比其他组更强的反应抑制缺陷。结果讨论了在反应抑制作为成瘾行为的危险因素可能的性别差异。(C) 2009爱思唯尔公司版权所有。
Poor response inhibition has been associated with a wide range of problem behaviours, including addictive behaviours, and could represent a general vulnerability factor. Standard tests of response inhibition have used neutral stimuli. Here we tested whether a deficit in response inhibition in heavy drinkers would be stronger for stimuli related to their problem (alcohol) or not. Response inhibition was assessed with a stop signal task, using four classes of pictures: alcohol-related, soft drinks, erotic (control appetitive categories) and neutral pictures. Participants were 32 heavy and 32 light drinkers. An equal amount of men and women were tested in both drinking groups, in view of recent studies reporting that response disinhibition may be most pronounced in heavy drinking women. Main results were first that no domain-specific differences in response inhibition were found in both groups. Second, heavy drinking females showed stronger response inhibition deficits than other groups. Results are discussed in light of a possible gender difference in response inhibition as a risk factor for addictive behaviours. (C) 2009 Elsevier Inc. All rights reserved.