The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial
The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial
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DOI：
10.1002/ptr.6328
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发表时间：
2019-05-01
影响因子：
7.2
通讯作者：
Hedayati, Mehdi
中科院分区：
文献类型：
--
作者：
Adibian, Mahsa;Hodaei, Homa;Hedayati, Mehdi
糖尿病是人类最常见和重要的代谢性疾病之一。姜黄素是姜黄中发现的一种天然多酚，由于其抗糖尿病、抗炎和抗氧化的特性，可以用于治疗糖尿病并发症。在本双盲随机临床试验中，44例2型糖尿病患者随机分为姜黄素组和安慰剂组。患者每天服用1500毫克姜黄素或安慰剂，持续10周。在基线和研究结束时测量人体测量值。在研究开始和结束时禁食12小时后测定血清甘油三酯（TG）、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、高敏c反应蛋白和脂联素浓度。姜黄素组血清平均TG水平较基线降低（109 +/- 36比124 +/- 36，p < 0.05）。研究结束时，姜黄素组高敏c反应蛋白平均浓度较对照组降低（2.9 +/- 2.9 vs. 3.4 +/- 4.2; p < 0.05）。研究结束时，与安慰剂组相比，治疗组的平均血清脂联素浓度升高（64 +/- 3 vs. 63 +/- 4; p < 0.05）。目前的研究结果表明，姜黄素的摄入可能通过降低TG水平和炎症指标来减少糖尿病并发症。
Diabetes mellitus is one of the most common and important metabolic diseases in human. Curcumin, which is a natural polyphenol found in turmeric, can be used in treatment of diabetes complications for its antidiabetic, anti-inflammatory, and antioxidant properties. In this double-blind randomized clinical trial, 44 patients with Type 2 diabetes randomly assigned to curcumin or placebo group. Patients consumed either 1,500-mg curcumin or placebo daily for 10 weeks. Anthropometric measurements were measured at baseline and at the end of the study. Serum concentrations of triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and adiponectin were determined after 12-hr fasting at the beginning and end of study. The mean serum level of TG decreased in curcumin group compared with baseline (109 +/- 36 vs. 124 +/- 36; p < 0.05). At the end of study, the mean concentration of high-sensitivity C-reactive protein decreased in the curcumin group compared to the control (2.9 +/- 2.9 vs. 3.4 +/- 4.2; p < 0.05). The mean serum concentration of adiponectin increased (64 +/- 3 vs. 63 +/- 4; p < 0.05) in the treatment group compared with the placebo at the end of the study. The results of the current study indicate that curcumin consumption may reduce diabetes complications through decreasing TG level as well as indicators of inflammation.