STRUCTURAL EVIDENCE THAT ENDOTHELIAL-CELL GROWTH-FACTOR-BETA IS THE PRECURSOR OF BOTH ENDOTHELIAL-CELL GROWTH FACTOR-ALPHA AND ACIDIC FIBROBLAST GROWTH-FACTOR
STRUCTURAL EVIDENCE THAT ENDOTHELIAL-CELL GROWTH-FACTOR-BETA IS THE PRECURSOR OF BOTH ENDOTHELIAL-CELL GROWTH FACTOR-ALPHA AND ACIDIC FIBROBLAST GROWTH-FACTOR
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DOI：
10.1073/pnas.83.19.7216
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发表时间：
1986-10-01
影响因子：
11.1
通讯作者：
MACIAG, T
中科院分区：
文献类型：
--
作者：
BURGESS, WH;MEHLMAN, T;MACIAG, T
Two endothelial cell growth factors (ECGF) have been purified from bovine brain and termed .alpha.- and .beta.-ECGF [Burgess, W.H., Mehlman, T., Friesel, R., Johnson, W. V. and Maciag, T. (1985) J. Biol. Chem. 260, 11389-11392]. Amino acid sequence analysis indicates that .beta.-ECGF represents a 20-amino acid amino-terminal extension of .alpha.-ECGF and a 14 amino acid amino-terminal extension of acidic fibroblast growth factor. These data indicate that both .alpha.-ECGF and acidic fibroblast growth factor may be derived from .beta.-ECGF by posttranslational processing. Analysis of the amino-terminal 14 residues of .beta.-ECGF by fast-atom-bombardment mass spectrometry established the amino acid sequence of this region and the identity of the blocking group at the amino terminus (acetyl).
