The clinical features, diagnosis and classification of dermatomyositis
The clinical features, diagnosis and classification of dermatomyositis
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DOI：
10.1016/j.jaut.2013.11.005
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发表时间：
2014-02-01
影响因子：
12.8
通讯作者：
Doria, Andrea
中科院分区：
文献类型：
--
作者：
Iaccarino, Luca;Ghirardello, Anna;Doria, Andrea
皮肌炎(DM)是一种特发性炎症性肌病(IIM)，其特征是主要影响骨骼肌和皮肤的炎性浸润性病变。最常见和特殊的皮损包括Gottron丘疹、Gottron征和嗜日性皮疹。到目前为止，人们已经确定了不同的DM亚型，包括经典型DM、肌病型DM、肌病型DM、肌病后DM和DM皮炎。DM患者的恶性肿瘤发生率高于正常人群。在这些患者中，癌症发生在大约30%的病例中，男性和老年人的发病率更高。Bohan和Peter于1975年提出的诊断标准一直被广泛接受和使用，直到现在。在过去的十年中，肌肉免疫病理学、肌炎特异性自身抗体检测以及肌肉成像新技术的使用，如超声造影或磁共振成像，被引入到糖尿病患者的诊断工作中，导致了新的诊断标准的发展。(C)2014爱思唯尔有限公司。保留所有权利。
Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now encompassing classic DM, amyopathic DM, hypomyopathic DM, post-myopathic DM, and DM sine dermatitis.Patients with DM have a higher incidence rate of malignancy than the normal population. In these patients cancer occurs in about 30% of cases with higher occurrence in men and in elderly people.Bohan and Peter's diagnostic criteria, proposed in 1975, have been widely accepted and used until now. In the last ten years muscle immunopathology, myositis specific autoantibodies testing, and the use of new techniques of muscle imaging such as contrast-enhanced ultrasound or Magnetic Resonance Imaging have been introduced in the diagnostic work-up of patients with DM leading to the development of new diagnostic criteria. (C) 2014 Elsevier Ltd. All rights reserved.