Association study of neuregulin 1 gene with schizophrenia
Association study of neuregulin 1 gene with schizophrenia
复制标题
DOI：
10.1038/sj.mp.4001377
复制
发表时间：
2003-01-01
影响因子：
11
通讯作者：
Zhang, D
中科院分区：
文献类型：
--
作者：
Yang, JZ;Si, TM;Zhang, D
许多研究表明，8 p22-p12可能存在精神分裂症的易感位点。在该区域，候选基因neuregulin 1（NRG 1）可能在精神分裂症的发病机制中发挥作用。本研究采用基于PCR的限制性片段长度多态性方法和变性高效液相色谱技术，对246例中国汉族精神分裂症家系进行了NRG 1基因3个遗传变异（SNPs：rs3924999、rs 2954041、SNP 8 NRG 221533）与精神分裂症的连锁不平衡分析。传递不平衡检验分析显示，即使经过Bonferroni校正，两个传递的等位基因之间仍存在显著差异（rs3924999，P=0.007752; rs 2954041，P=0.0009309; SNP 8 NRG 221533，P=0.012606）。单倍型传递的总体chi（2）检验也显示了强关联（chi（2）=46.068，df=7，P
A number of studies have indicated that 8p22-p12 is likely to harbor schizophrenia susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may play a role in the pathogenesis of schizophrenia. Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. The transmission disequilibrium test analysis for each variant showed a significant difference between two transmitted alleles even after Bonferroni correction (rs3924999, P=0.007752; rs2954041, P=0.0009309; SNP8NRG221533, P=0.012606). The global chi(2) test for haplotype transmission also revealed a strong association (chi(2)=46.068, df=7, P