2 SODIUM-CHANNEL GENES IN DROSOPHILA - IMPLICATIONS FOR CHANNEL DIVERSITY
2 SODIUM-CHANNEL GENES IN DROSOPHILA - IMPLICATIONS FOR CHANNEL DIVERSITY
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DOI：
10.1073/pnas.86.6.2079
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发表时间：
1989-03-01
影响因子：
11.1
通讯作者：
TANOUYE, MA
中科院分区：
文献类型：
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作者：
RAMASWAMI, M;TANOUYE, MA
我们描述了两个与Ran钠离子通道蛋白高度同源的果蝇黑腹果蝇转录单位。其中一个定位在第二条染色体上，与一个钠离子通道基因相同，其部分序列已被报道[Salkoff，L.，Butler，A.，wei]。A.，Savarda，N.，Giffen，K.，Ifune，L.，Goodman，R.和Mandel，G.(1987)科学237,744-749]。另一个转录单位位于X染色体上的14C/D位置，靠近瘫痪的(Para)基因。PARA基因突变影响果蝇神经元的膜兴奋性[Ganetzky，B.和Wu。C.F.(1986)Annu.Genet牧师20、13-44]。序列比较表明，两个钠离子通道基因在进化的早期就出现了，在脊椎动物和无脊椎动物品系分化之前。
We describe two Drosophila melanogaster transcription units that are highly homologous to a ran Na+-channel proteins. One of these maps to the second chromosome and is identical to a Na+-channel gene whose partial sequence has been previously reported [Salkoff, L., Butler, A., Wei. A., Scavarda, N., Giffen, K., Ifune, L., Goodman, R. and Mandel, G. (1987) Science 237, 744-749]. The other transcription unit maps to position 14C/D, on the X chromosome, close to the paralyzed (para) gene. Mutations in para affect membrane excitability in Drosophila neurons [Ganetzky, B. and Wu. C. F. (1986) Annu. Rev. Genet. 20, 13-44]. Sequence comparisons suggest that two Na+-channel genes arose early in evolution, before the divergence of vertebrate and invertebrate lines.