Comparison of demographic and donation profiles and transfusion-transmissible disease markers and risk rates in previously transfused and nontransfused blood donors
Comparison of demographic and donation profiles and transfusion-transmissible disease markers and risk rates in previously transfused and nontransfused blood donors
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DOI：
10.1111/j.1537-2995.2004.04034.x
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发表时间：
2004-08-01
期刊：
影响因子：
2.9
通讯作者：
Busch, MP
中科院分区：
文献类型：
--
作者：
Wang, B;Higgins, MJ;Busch, MP
背景技术背景：对变异型克雅氏病输血传播的日益关注导致法国和英国无限期推迟输血供体。鲜为人知的是，但是，无限期推迟输血献血者的血液安全性和可用性的影响，在US.Study设计和方法：数据收集在1991年至2000年期间，在美国五个血液中心的同种异体捐赠。我们比较了输血和非输血献血者的献血特征、人类免疫缺陷病毒（HIV）、B肝炎病毒（HBV）和丙型肝炎病毒（HCV）的患病率和发病率。未报告的可延迟风险（UDR）和捐赠的原因进行了评估，从邮件调查的数据。结果：输血史的4.2%的捐助者报告。输血和非输血供体之间HIV和HBV的流行率和发病率相当。虽然两组的HCV发病率相似，但输血者的HCV患病率比非输血者的首次献血者高近3倍。UDR和献血的原因是相似的，在两组中，除了输血献血者不太可能献血的筛选测试结果（比值比，0.5; 95%置信区间，0.3-0.8）。结论：输血和非输血的献血者有相似的病毒感染率和可比的UDR，这表明无限期推迟输血献血者不太可能提高血液安全性。在对新出现的病原体的流行率和输血传播性有更多了解之前，美国对以前输血的供体无限期推迟似乎没有必要。
BACKGROUND: Increasing concern about transfusion transmission of variant Creutzfeldt-Jakob disease has resulted in indefinite deferral of transfused donors in France and the UK. Little is known, however, about the impact of indefinite deferral of transfused donors on blood safety and availability in the US.STUDY DESIGN AND METHODS: Data were collected on allogeneic donations at five US blood centers during 1991 through 2000. Donation characteristics, prevalence, and incidence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) were compared between transfused and nontransfused donors. Unreported deferrable risk (UDR) and reasons to donate were evaluated with data from a mail survey.RESULTS: Transfusion history was reported by 4.2 percent of donors. Prevalence and incidence of HIV and HBV were comparable between transfused and nontransfused donors. Although HCV incidence was similar in both groups, HCV prevalence was nearly three times higher in transfused than in nontransfused first-time donors. UDR and reasons to donate were similar in the two groups, except transfused donors were less likely to donate for screening test results (odds ratio, 0.5; 95% confidence interval, 0.3-0.8).CONCLUSION: Transfused and nontransfused donors had similar viral incidence and comparable UDR, suggesting that indefinite deferral of transfused donors would unlikely improve blood safety. Until more is known about the prevalence and transfusion transmissibility of emerging agents, indefinite deferral of previously transfused donors in the US does not appear warranted.