Reproducibility of Kidney Perfusion Measurements With Arterial Spin Labeling at 1.5 Tesla MRI Combined With Semiautomatic Segmentation for Differential Cortical and Medullary Assessment.
Reproducibility of Kidney Perfusion Measurements With Arterial Spin Labeling at 1.5 Tesla MRI Combined With Semiautomatic Segmentation for Differential Cortical and Medullary Assessment.
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DOI：
10.1097/md.0000000000003083
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发表时间：
2016-03
期刊：
影响因子：
1.6
通讯作者：
Kistner I
中科院分区：
文献类型：
--
作者：
Hammon M;Janka R;Siegl C;Seuss H;Grosso R;Martirosian P;Schmieder RE;Uder M;Kistner I
动脉自旋标记 (ASL) 磁共振成像是一种测量器官灌注的无创方法。本研究的目的是评估半自动分割 ASL 肾脏灌注测量的重现性，该分割允许单独量化皮质和髓质灌注。 14名健康志愿者的右肾检查2次6次（每次3次）。每次检查之间有10分钟的暂停，两次检查之间有14天的间隔。使用定制的半自动分割软件确定皮质、髓质和全肾实质灌注。计算方差系数（CV）和组内相关性（ICC）。平均全肾、皮质肾和髓质肾灌注分别为 307.26±25.65、337.10±34.83 和 279.61±26.73mL/min/100g。在第 1 节中，整个肾脏、皮质和髓质的平均灌注分别为 307.08±26.91、336.79±36.54 和 279.60±27.81mL/min/100g，在第 2 节中，分别为 307.45±24.65、337.41±33.48 和 279.61±25.94mL/min/100g（P>0.05；R2=0.60/0.59/0.54）。对于全肾、皮质肾和髓质肾灌注，总 ICC/CV 分别为 0.97/3.43±0.86%、0.97/4.19±1.33% 和 0.96/4.12±1.36%。测量结果没有显着差异，并且显示出非常好的相关性（P > 0.05；R2 = 0.75/0.76/0.65）。 ASL 肾脏测量与独立于操作员的半自动分割相结合，揭示了皮质、髓质和全肾灌注的高相关性和低方差。
Magnetic resonance imaging with arterial spin labeling (ASL) is a noninvasive approach to measure organ perfusion. The purpose of this study was to evaluate the reproducibility of ASL kidney perfusion measurements with semiautomatic segmentation, which allows separate quantification of cortical and medullary perfusion. The right kidneys of 14 healthy volunteers were examined 6 times on 2 occasions (3 times at each occasion). There was a 10-minute pause between each examination and a 14-day interval between the 2 occasions. Cortical, medullary, and whole kidney parenchymal perfusion was determined with customized semiautomatic segmentation software. Coefficient of variances (CVs) and intraclass correlations (ICCs) were calculated. Mean whole, cortical, and medullary kidney perfusion was 307.26 ± 25.65, 337.10 ± 34.83, and 279.61 ± 26.73 mL/min/100 g, respectively. On session 1, mean perfusion for the whole kidney, cortex, and medulla was 307.08 ± 26.91, 336.79 ± 36.54, and 279.60 ± 27.81 mL/min/100 g, respectively, and on session 2, 307.45 ± 24.65, 337.41 ± 33.48, and 279.61 ± 25.94 mL/min/100 g, respectively (P > 0.05; R2 = 0.60/0.59/0.54). For whole, cortical, and medullary kidney perfusion, the total ICC/CV were 0.97/3.43 ± 0.86%, 0.97/4.19 ± 1.33%, and 0.96/4.12 ± 1.36%, respectively. Measurements did not differ significantly and showed a very good correlation (P > 0.05; R2 = 0.75/0.76/0.65). ASL kidney measurements combined with operator-independent semiautomatic segmentation revealed high correlation and low variance of cortical, medullary, and whole kidney perfusion.