Role of thiol-containing polyethylene glycol (thiol-PEG) in the modification process of gold nanoparticles (AuNPs): Stabilizer or coagulant?
Role of thiol-containing polyethylene glycol (thiol-PEG) in the modification process of gold nanoparticles (AuNPs): Stabilizer or coagulant?
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含硫醇聚乙二醇（thiol-PEG）在金纳米颗粒（AuNPs）改性过程中的作用：稳定剂还是凝固剂？
DOI：
10.1016/j.jcis.2013.04.020
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发表时间：
2013-08-15
影响因子：
9.9
通讯作者：
Yuan, Zhi
中科院分区：
文献类型：
--
作者：
Wang, Wei;Wei, Qin-Qin;Yuan, Zhi
金纳米颗粒(AuNPs)作为生物传感器和药物载体，以及成像和热疗试剂具有巨大的潜力。含有硫醇的聚乙二醇(以下简称为硫醇-聚乙二醇)是一种广泛应用于修饰金纳米粒子并使其在各种环境中稳定的大分子配体。本工作合成了一系列不同相对分子质量(M-w)的聚乙二醇化聚乙二醇化金纳米粒(PEGylated AuNPs)。然后考察了聚乙二醇化的AuNPs的饱和封端密度、电荷屏蔽能力和稳定性。结果表明，高分子量聚乙二醇组比低分子量聚乙二醇组更稳定金纳米粒子，屏蔽表面电荷，但后者具有更高的饱和封端密度。更重要的是，在AuNPs的稳定过程中，聚乙二醇具有最大的凝聚浓度(MCC)和临界稳定浓度(CSC)。硫醇-聚乙二醇只有在其浓度高于CSC时才能起到AuNP稳定剂的作用。此外，硫醇-聚乙二醇组分加速了AuNPs的聚集，并在MCC处达到峰值。这些结果对于认识硫醇-聚乙二醇对AuNPs稳定性的影响具有重要意义。(C)2013 Elsevier Inc.保留所有权利。
Gold nanoparticles (AuNPs) have significant potential as biosensors and drug delivery vehicles, as well as imaging and thermotherapy agents. Thiol-containing polyethylene glycol (PEG), hereafter denoted as thiol-PEG, is widely used as a macromolecular ligand for modifying AuNPs and stabilizing them under various environments. In this work, a series of thiol-PEG-modified AuNPs (PEGylated AuNPs) with different PEG molecular weights (M-w) were synthesized. The saturated capping density, charge-screening ability, and stability of the PEGylated AuNPs were then examined. The results showed that high-M-w PEG stabilized the AuNPs and screened the surface charge better than low-M-w PEG, but the latter showed higher saturated capping density. More importantly, PEG exhibited the maximum coagulation concentration (MCC) and critical stabilization concentration (CSC) in the stabilizing process of the AuNPs. Thiol-PEG acted as an AuNP stabilizer only when its concentration was higher than the CSC. Otherwise, thiol-PEG accelerated AuNPs aggregation, which reached the peak level at the MCC. These results were significant in recognizing the influence of thiol-PEG on the stability of AuNPs. (C) 2013 Elsevier Inc. All rights reserved.