Cereblon is expressed in the retina and binds to voltage-gated chloride channels
Cereblon is expressed in the retina and binds to voltage-gated chloride channels
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DOI：
10.1016/j.febslet.2009.01.018
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发表时间：
2009-02-18
期刊：
影响因子：
3.5
通讯作者：
Enz, Ralf
中科院分区：
文献类型：
--
作者：
Hohberger, Bettina;Enz, Ralf
中枢神经系统的功能取决于相互作用的蛋白质对离子通道的正确调节。在这里，我们确定cereblon作为一个新的相互作用的电压门控氯离子通道CIC-2。CIC-2 C-末端的远端区域与cereblon的Lon结构域相互作用。Cereblon在包括视网膜在内的几个大脑区域中表达。在那里，我们检测到cereblon在核和突触层和本地化的蛋白质在相同的亚细胞区域的双极细胞体先前报道表达CIC-2。我们的数据表明，cereblon可能与电压门控氯离子通道在中枢神经系统。(C)2009年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
The function of the central nervous system depends on the correct regulation of ion channels by interacting proteins. Here, we identified cereblon as a new interactor of the voltage-gated chloride channel CIC-2. A distal region of the CIC-2 C-terminus interacts with the Lon domain of cereblon. Cereblon is expressed in several brain regions including the retina. There, we detected cereblon in nuclear and synaptic layers and localized the protein in the same subcellular region of bipolar cell bodies previously reported to express CIC-2. Our data suggest that cereblon might be associated with voltage-gated chloride channels in the central nervous system. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.