Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study
Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study
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DOI：
10.1016/s0021-9150(00)00586-4
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发表时间：
2001-02-15
期刊：
影响因子：
5.3
通讯作者：
Tracy, RP
中科院分区：
文献类型：
--
作者：
Pankow, JS;Folsom, AR;Tracy, RP
炎症被认为在动脉粥样硬化的病因和结果中起着核心作用。动物研究以及体外和体内的人类研究表明，宿主因素调节炎症反应的大小和程度。我们研究了三种系统炎症标志物(C-反应蛋白)的家族聚集性。在美国四个社区进行的一项大型横断面研究中，白血球计数(WBC)和白蛋白(Alb)。我们发现了CRP水平以及WBC和白蛋白水平的大量遗传力(35-40%)的证据。可以忽略不计的配偶相关性表明，共同的家庭环境对这些特质几乎没有影响。社会人口统计因素的组合(年龄。中心、教育)。行为和生活方式因素(吸烟、饮酒、激素替代疗法)、肥胖和脂肪模式以及普遍存在的糖尿病可以解释这些特征的个体间变异性的13-30%。没有证据表明这些炎症表型与染色体2Q上的白介素2 L基因簇中的微卫星标记有关。该区域包含几个慢性炎症性疾病的候选基因。我们的发现表明，CRP水平、白蛋白水平和WBC至少部分由遗传因素决定。进一步努力确定影响这些性状的基因座是有必要的。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Inflammation is thought to play a central role in the etiology and outcome of atherosclerosis. Animal studies as well as in vitro and in vivo human studies suggest that host factors modulate the magnitude and extent of inflammatory responses. We investigated familial aggregation of three systemic markers of inflammation (C-reactive protein (CRP). white blood cell count (WBC), and albumin) in a large, cross-sectional study conducted in four US communities. We Found evidence of substantial heritability (35-40%) for CRP levels as well as for WBC and albumin levels. Negligible spouse correlations suggested little influence of shared household environment on these: traits. The combination of sociodemographic Factors (age. center, education). behavioral and lifestyle factors (cigarette smoking, alcohol intake, hormone replacement therapy), obesity and fat patterning, and prevalent diabetes explained 13-30% the interindividual variability of these traits. There was no evidence that these inflammation phenotypes were linked to a microsatellite marker in the interleukin-l gene cluster on chromosome 2q. a region that includes several candidate genes for chronic inflammatory diseases. Our findings suggest that CRP levels, albumin levels, and WBC are determined at least partially by genetic factors. Further efforts to identify gene loci affecting these traits are warranted. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.